PHARMACOKINETICS OF 18F-SETOPERONE IN PATIENTS W/SEASONAL AFFECTIVE DISORDER SAD

1.）确定18F-司妥哌隆PET扫描是否会定义差异 在5 HT 2受体占有率和显示的季节性 情感障碍与正常人相比，志愿者是否 情感性精神障碍的程度与患者的心理状态有一定的定量关系， 这些PET扫描结果2.）以确定患者是否对 临床上接受治疗的患者的PET扫描会显示正常化 研究结果，并从他们的治疗前研究的显着变化。

1.) To determine if 18F-setoperone PET scanning will define a difference in 5HT2 receptor occupancy and display in patients with seasonal affective disorder when compared with normal, volunteers and whether the extent of the affective disorder will bear a quantatative relationship th these PET scan findings. 2.) To determine if patients responding clinically to therapy will manifest a normalization in their PET scan findings, and a significant change from their pre-therapy study.