PHARMACOKINETICS OF 18F-SETOPERONE IN PATIENTS W/SEASONAL AFFECTIVE DISORDER SAD

18F-SETOPERONE 在季节性情感障碍 SAD 患者中的药代动力学

• 批准号: 6246684
• 负责人: ROBERT H RUBIN
• 金额: $ 6.54万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246684
• 关键词: clinical research; clinical trials; drug screening /evaluation; fluorine; human subject; human therapy evaluation; mental disorder chemotherapy; pharmacokinetics; positron emission tomography; radionuclides; seasonal affective disorder; serotonin; serotonin receptor

1.) To determine if 18F-setoperone PET scanning will define a difference in 5HT2 receptor occupancy and display in patients with seasonal affective disorder when compared with normal, volunteers and whether the extent of the affective disorder will bear a quantatative relationship th these PET scan findings. 2.) To determine if patients responding clinically to therapy will manifest a normalization in their PET scan findings, and a significant change from their pre-therapy study.

1)要确定18F-setopone PET扫描是否会定义差异 5HT2受体在季节性高血压患者中的占据和显示 情感性精神障碍与正常人相比，志愿者是否 情感障碍的程度将与 这些正电子发射计算机断层扫描发现。2.)以确定患者是否有反应 临床上接受治疗的患者的正电子发射计算机断层扫描将显示正常化。 结果，与他们治疗前的研究相比有了显著的变化。