PHARMACOKINETICS OF 18F SETOPERONE IN SEASONAL AFFECTIVE DISORDER (SAD)

1.）确定18F-司妥哌隆PET扫描是否会定义差异 在季节性情感障碍患者中的5 HT 2受体占有率和显示率 与正常人相比，志愿者的障碍程度是否 情感性精神障碍与这些PET之间存在定量关系 扫描结果。 2.）为了确定患者是否对 治疗将在他们的PET扫描结果中表现出正常化， 与治疗前研究相比有显著变化。

1.) To determine if 18F-setoperone PET scanning will define a difference in 5HT2 receptor occupancy and display in patients with seasonal affective disorder when compared with normal, volunteers and whether the extent of the affective disorder will bear a quantatative relationship th these PET scan findings. 2.) To determine if patients responding clinically to therapy will manifest a normalization in their PET scan findings, and a significant change from their pre-therapy study.