PHARMACOKINETICS OF 18F SETOPERONE IN SEASONAL AFFECTIVE DISORDER (SAD)

18F Setoperone 在季节性情感障碍 (SAD) 中的药代动力学

• 批准号: 6115560
• 负责人: ROBERT H RUBIN
• 金额: $ 4.08万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6115560
• 关键词: clinical research; clinical trials; drug screening /evaluation; fluorine; human subject; human therapy evaluation; mental disorder chemotherapy; pharmacokinetics; positron emission tomography; radionuclides; seasonal affective disorder; serotonin; serotonin receptor

1.) To determine if 18F-setoperone PET scanning will define a difference in 5HT2 receptor occupancy and display in patients with seasonal affective disorder when compared with normal, volunteers and whether the extent of the affective disorder will bear a quantatative relationship th these PET scan findings. 2.) To determine if patients responding clinically to therapy will manifest a normalization in their PET scan findings, and a significant change from their pre-therapy study.

1.） 以确定是否18F-setoperone PET扫描将定义差异