SONOPHORETIC TRANSDERMAL GLUCOSE EXTRACTION

评估低频超声是否能在体内通过人体皮肤提取葡萄糖。找出通过声泳法在皮肤上提取足量葡萄糖所需的最短时间。评估以这种方式提取的葡萄糖量是否与患者的血糖浓度相关。评估血糖水平的动态变化是否会导致超声提取葡萄糖量的可检测变化，并研究这两种变化之间的时间滞后。评估与使用低频声泳术进行无创血糖测量相关的患者依从性问题。

To assess whether application of low frequency ultrasound extracts glucose across the human skin in vivo. To find out the minimum time required to extract sufficient amount of glucose across the skin by sonophoresis. To assess whether the amount of glucose extracted in this manner correlates with the blood glucose concentrations of patients. To assess whether a dynamic change in blood glucose level results in a detectable change in the amount of glucose extracted by sonophoresis and investigate the time lag between these two changes. To assess patient compliance related issues associated with using low-frequency sonophoresis for non-invasive blood-glucose measurements.