PET STUDIES OF THE 5HT2 RECEPTOR USING 18F-SETOPERONE AND CP 88,059

使用 18F-Setoperone 和 CP 88,059 对 5HT2 受体进行 PET 研究

• 批准号: 3741375
• 负责人: ROBERT H RUBIN
• 金额: --
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3741375
• 关键词: antipsychotic agents; dopamine antagonists; fluorine; human subject; pharmacokinetics; positron emission tomography; radiotracer; receptor binding; serotonin inhibitor; serotonin receptor

This study will establish the time course of 5HT2 receptor occupancy in human volunteers, utilizing 18F-setoperone and PET imaging to define the pharmacokinetics of receptor occupancy in normal human brain. Additionally, it is to delineate the effects of CP-88,059 an antipsychotic drug with affinity both for serotonin 5HT2 and dopamine D2, on the pharmacokinetics of receptor binding by 18F-setoperone.

这项研究将建立5 HT 2受体占用的时间过程， 人类志愿者，利用18F-setoperone和PET成像来定义 正常人脑中受体占有率的药代动力学。 此外，它是描绘CP-88，059的作用， 对5-羟色胺5 HT 2和多巴胺D2都有亲和力的抗精神病药物， 对18F-司托哌隆受体结合的药代动力学的影响。