VIRAL ACTIVATION TRANSFUSION STUDY (VATS)

这项研究旨在确定将同种异体血液输入到 HIV-1感染者导致免疫激活和随后的诱导 HIV-1和/或CMV复制的可能性，以及这是否会对 临床预后。这项研究将确定捐赠者白细胞的作用 在产生这种激活的过程中，通过检查移除 白细胞滤过对病毒诱导和临床进展的影响。 最后，这项研究将检验循环的长期持久性 输血后供者淋巴细胞以确定隐匿性移植物抗- 宿主疾病可能是艾滋病患者的一种重要并发症。

This study is designed to determine if transfusion of allogenic blood to HIV-1-infected persons leads to immune activation and consequent induction of HIV-1 and/or CMV replication, and whether this adversely affects clinical prognosis. The study will determine the role of donor leukocytes in producing this activation by examining the effect of removing leukocytes by filtration on viral induction and clinical progression. Finally, the study will examine the long-term persistence of circulating donor lymphocytes after transfusion to determine if occult graft-versus- host disease may be a significant ocurrence in AIDS patients.