ANTITUBERCULOSIS AGENTS IN HIV INFECTED PERSONS W/ TB

这是一项多中心的药代动力学研究，接受利福平、异烟肼、乙胺丁醇或吡津酰胺等2种或2种以上药物治疗的HIV感染的结核患者将在两个时间点进行血药浓度测定，以努力更多地了解这些药物在这些受试者中的吸收和药代动力学。血液样本将在服用研究药物后2、6和10小时采集，一次在每日治疗阶段的第10-14天之间，一次在间歇给药方案期间。

This is a multicenter, pharmacokinetic study whereby HIV-infected subjects with culture-confirmed tuberculosis (TB), who are treated with any 2 or more of the following : rifampin, INH, ethambutol, orpyrazinamide, will have serum drug concentration determinations performed at two time points, in an effort to learn more about the absorption and the pharmacokinetics of these drugs in these subjects. Blood specimens will be collected at 2, 6, and 10 hours after the administration of the study medication, once between days 10-14 of a phase of daily treatment and once while on an intermittent dose regimen.