VIRAL ACTIVATION TRANSFUSION STUDY (VATS)

本研究旨在确定向HIV-1感染者输注同种异体血是否会导致免疫激活和随后诱导HIV-1和/或CMV复制，以及这是否会对临床预后产生不利影响。 本研究将通过检查过滤去除白细胞对病毒诱导和临床进展的影响，确定供体白细胞在产生这种激活中的作用。 最后，本研究将检查输血后循环供体淋巴细胞的长期持续性，以确定隐匿性移植物抗宿主病是否可能是艾滋病患者的一个重要事件。 GCRC将协助输注同种异体血。

This study is designed to determine if transfusion of allogenic blood to HIV-1-infected persons leads to immune activation and consequent induction of HIV-1 and/or CMV replication, and whether this adversely affects clinical prognosis. The study will determine the role of donor leukocytes in producing this activation by examining the effect of removing leukocytes by filtration on viral induction and clinical progression. Finally, the study will examine the long-term persistence of circulating donor lymphocytes after transfusion to determine if occult graft-versus-host disease may be a significant ocurrence in AIDS patients. The GCRC will assist with administration of transfusion of allogenic blood.