ANTITUBERCULOSIS AGENTS IN HIV INFECTED PERSONS W/ TB

这是一项多中心药代动力学研究，在此研究中，接受利福平、INH、乙胺丁醇或吡嗪酰胺两种或两种以上治疗的hiv感染患者，将在两个时间点进行血清药物浓度测定，以进一步了解这些药物在这些受试者中的吸收和药代动力学。将在给药后2、6和10小时采集血样，在每日治疗阶段的第10-14天之间采集一次，在间歇给药方案中采集一次，每周3次或每周2次，在每日给药方案完成后8周内采集一次。

This is a multicenter, pharmacokinetic study whereby HIV-infected subjects with culture-confirmed tuberculosis (TB), who are treated with any 2 or more of the following : rifampin, INH, ethambutol, or pyrazinamide, will have serum drug concentration determinations performed at two time points, in an effort to learn more about the absorbtion and the pharmacokinetics of these drugs in these subjects. Blood specimens will be collected at 2, 6, and 10 hours after the administration of the study medication, once between days 10-14 of a phase of daily treatment and once while on an intermittent dose regimen 3-times-per-week or 2-times-per-week within 8 weeks of completion of a daily dosing regimen.