VIRAL ACTIVATION TRANSFUSION STUDY (VATS)

本研究旨在确定是否输注同种异体血 对HIV-1感染者的免疫激活， 诱导HIV-1和/或CMV复制，以及这是否不利 影响临床预后。 这项研究将确定捐助者的作用 白细胞在产生这种激活通过检查的影响， 过滤除白细胞对病毒诱导和临床 进展 最后，研究将考察长期持续性 输血后循环供体淋巴细胞，以确定是否 隐匿性移植物抗宿主病可能是艾滋病的一个重要发病因素 患者

This study is designed to determine if transfusion of allogenic blood to HIV-1-infected persons leads to immune activation and consequent induction of HIV-1 and/or CMV replication, and whether this adversely affects clinical prognosis. The study will determine the role of donor leukocytes in producing this activation by examining the effect of removing leukocytes by filtration on viral induction and clinical progression. Finally, the study will examine the long-term persistence of circulating donor lymphocytes after transfusion to determine if occult graft-versus-host disease may be a significnata ocurrence in AIDS patients.