FOSCARNET CREAM FOR THE TREATMENT OF MUCOCUTANEOUS HERPES SIMPLEX

免疫功能低下的艾滋病毒患者感染人类的风险增加 疱疹病毒(HSV)。然而，之前的药物阿昔洛韦 用于治疗单纯疱疹病毒最近被证明对一些 单纯疱疹病毒株。磷甲酸钠在体外对所有HSV都有活性 浓度为100-300微米。尽管IV Foscarnet已经被证明 为了让这些患者受益，这项试验将确定一项 局部用药可以看到副作用较少的临床益处 治疗。

Immunocompromised patients with HIV are at increased risk for human herpes virus (HSV). However, Acyclovir which has been the previous drug for treatment of HSV has recently been shown to prove resistant to some strains of HSV. Foscarnet is active in vitro against all HSV at concentrations of 100 - 300uM. And although IV Foscarnet has been shown to have benefit in these patients this trial will determine whether a clinical benefit with fewer side effects can be seen with topical treatment.