REGULATIION OF CANCER CELL GROWTH AND BEHAVIOR

癌细胞生长和行为的调节

• 批准号: 2463818
• 负责人: I PASTAN
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2463818
• 关键词: breast neoplasms; cell growth regulation; colon neoplasms; epithelium; gene expression; genetic regulation; neoplasm /cancer genetics; neoplastic cell; neoplastic growth

Dr. Ulrich Brinkmann has recently identified a gene termed CAS which encodes a phosphoprotein that is localized to microtubules and to the mitotic spindle. CAS is the mammalian homologue of CSE1, a yeast gene which controls mitosis. Several lines of evidence suggest CAS has a similar role in mammalian cells: One is that CAS levels correlate with cell growth. Another is that CAS antisense RNA blocks mitosis and Gl-S transition in Hela cells. Because CAS expression is high in proliferating cells, anti-CAS antibodies can be used as a proliferation marker in leukemia/lymphoma cells. CAS is located at 20q13, a region that is amplified in some breast, colon and uroepithelial cells. We are investigating the role of CAS in these types of tumors.

乌尔里希·布林克曼博士最近发现了一种叫做CAS的基因