REGULATIION OF CANCER CELL GROWTH AND BEHAVIOR

Ulrich Brinkmann博士最近发现了一种名为CAS的基因， 编码一种磷蛋白，定位于微管和 有丝分裂纺锤体 CAS是酵母基因CSE 1的哺乳动物同源物 控制有丝分裂 几条证据表明，CAS有一个 在哺乳动物细胞中的类似作用：一是CAS水平与 细胞生长 二是CAS反义RNA阻断有丝分裂和Gl-S 在Hela细胞中转化。 因为CAS表达在 在增殖细胞中，抗CAS抗体可用作增殖抑制剂。 白血病/淋巴瘤细胞中的标志物。 CAS位于20 q13， 在一些乳腺、结肠和泌尿上皮细胞中被放大。 我们 正在研究CAS在这些类型的肿瘤中的作用。

Dr. Ulrich Brinkmann has recently identified a gene termed CAS which encodes a phosphoprotein that is localized to microtubules and to the mitotic spindle. CAS is the mammalian homologue of CSE1, a yeast gene which controls mitosis. Several lines of evidence suggest CAS has a similar role in mammalian cells: One is that CAS levels correlate with cell growth. Another is that CAS antisense RNA blocks mitosis and Gl-S transition in Hela cells. Because CAS expression is high in proliferating cells, anti-CAS antibodies can be used as a proliferation marker in leukemia/lymphoma cells. CAS is located at 20q13, a region that is amplified in some breast, colon and uroepithelial cells. We are investigating the role of CAS in these types of tumors.