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PLASMA MEMBRANE PROTEINS IN THE REGULATION OF CELL BEHAVIOR AND DRUG RESISTANCE

PLASMA MEMBRANE PROTEINS IN THE REGULATION OF CELL BEHAVIOR AND DRUG RESISTANCE
质膜蛋白在细胞行为和耐药性调节中的作用
批准号：
3963038
负责人：
I PASTAN
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3963038
关键词：
Golgi apparatus antineoplastic antibiotics cell growth regulation cell membrane colchicine combination chemotherapy complementary DNA diltiazem doxorubicin drug resistance epidermal growth factor gene expression genetic library genetic manipulation ligands lysosomes macroglobulins membrane activity membrane permeability molecular biology molecular cloning mutant natural gene amplification neoplasm /cancer genetics organelles quinidine receptor mediated endocytosis tissue /cell culture verapamil vinblastine

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英文摘要
Human KB cells which are resistant to adriamycin (A), vinblastine (V), colchicine (C) and actinomycin (D) (AcD) have been shown to contain an amplified gene (mdr-l) responsible for the drug resistance. A fragment of this gene has been cloned and used to screen a cDNA library and identify cDNAs encoding a 170 kdalton membrane protein also found to be increased in multidrug resistant cells. The 170 kd protein binds vinblastine and related drugs, and this binding is overcome by drugs such as verapamil, quinidine, and diltiazem which overcome multidrug resistance. The levels of expression of the mdr-l gene are being measured in human cancers.
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GENETIC ANALYSIS OF THE MULTIDRUG RESISTANCE PHENOTYPE IN TUMOR CELLS
MONOCLONAL ANTIBODIES TO CANCER CELLS
REGULATION OF GENE ACTIVITY
GENETIC ANALYSIS OF THE MULTIDRUG RESISTANCE PHENOTYPE IN TUMOR CELLS