REGULATIION OF CANCER CELL GROWTH AND BEHAVIOR

癌细胞生长和行为的调节

• 批准号: 6161111
• 负责人: I PASTAN
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161111
• 关键词: biomarker; breast neoplasms; cell growth regulation; colon neoplasms; epithelium; gene expression; genetic regulation; microtubules; mitotic spindle apparatus; neoplasm /cancer genetics; neoplastic cell; neoplastic growth

We have identified a gene termed CAS which encodes a protein that is localized to microtubules and to the mitotic spindle. CAS is the mammalian homologue of CSE1, a yeast gene which controls mitosis. Several lines of evidence suggest CAS has a similar role in mammalian cells. CAS is located at 20q13, a region that is amplified in some breast, colon and uroepithelial cells. We are investigating the role of CAS in these types of tumors. Because CAS expression is high in proliferating cells, anti-CAS antibodies can be used as a proliferation marker in leukemia and lymphoma cells. Another interesting feature of CAS is that it is abundantly expressed in several nonproliferating tissues. We have found these tissues have spliced forms of CAS mRNA which may confer different functions in these tissues.

我们已经确定了一种名为CAS的基因，它编码一种蛋白质，这种蛋白质 定位于微管和有丝分裂纺锤体。中科院是 控制有丝分裂的酵母基因CSE1的哺乳动物同源物。 几条证据表明CAS在哺乳动物中也有类似的作用 细胞。CAS位于20q13，该区域在一些基因中被扩增 乳腺、结肠和尿路上皮细胞。我们正在调查他所扮演的角色 在这些类型的肿瘤中的CA。因为CAS的表达很高 细胞增殖时，抗CAS抗体可用作增殖 白血病和淋巴瘤细胞中的标志物。的另一个有趣的特性 CAS是它在几种非增殖性疾病中大量表达 纸巾。我们发现这些组织具有剪接形式的CAS mRNA 它们可能在这些组织中发挥不同的功能。