NUTRITIONAL STATUS IN RELATION TO HORMONE RELATED CANCER

与激素相关癌症相关的营养状况

• 批准号: 2463908
• 负责人: R N HOOVER
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2463908
• 关键词: African American; Asian Americans; adipose tissue; age difference; alcoholic beverage consumption; body height; body physical characteristic; body weight; breast neoplasms; cancer risk; caucasian American; clinical research; dietary constituent; hormone regulation /control mechanism; hormone related neoplasm /cancer; human subject; human tissue; interview; nutrient intake activity; nutrition; nutrition related tag; prostate neoplasms; uterus neoplasms

In studies of breast, endometrial, and prostate cancers, the relationships of dietary intakes and anthropometry were investigated. In two case-control studies of breast cancer in young U.S. women and in Asian-American women, height was a strong predictor of risk. Higher weight was associated with decreased risk in the young U.S. women and the youngest Asian-American women. Investigation of hormone levels among premenopausal controls showed that serum estradiol levels were lower among heavy compared with thin women, perhaps explaining the reduced risk of this cancer among young, heavy women. In older Asian-American women, however, risk steadily increased with both recent adiposity and recent weight gain. Further, increased risk with adiposity was shown to be related to age at diagnosis in a prospective study of breast cancer, with the highest risk for heavy women diagnosed at age 65 or older. A review of body weight and risk of breast and endometrial cancers suggests that avoidance of weight gain and accumulation of central body fat in adulthood may reduce risk of these cancers in older women. Percent fat in the diet was not related to increased risk of breast cancer but dietary habits that may be proxies for dietary patterns were related to breast cancer risk in a screening population in the U.S.. High intake of soy, mainly tofu, was found to be associated with reduced risk of breast cancer among Asian-American women. Information from mothers of cases and controls were analyzed and showed that having been breast-fed as an infant was associated with reduced risk of breast cancer among young U.S. women. Compared with never drinkers, high intake of alcohol was related to increased risk of prostate cancer among whites and blacks in a large case-control study. Similarly, increased risk of breast cancer among young women was observed for high intakes of alcohol, with recent intake being more important than consumption at earlier time periods.

在乳腺癌、子宫内膜癌和前列腺癌的研究中， 研究了膳食摄入量和人体测量学的关系。 在两项关于美国年轻女性乳腺癌的病例对照研究中， 对于亚裔美国女性来说，身高是风险的有力预测指标。 更高 体重与美国年轻女性的风险降低有关 最年轻的亚裔美国女性。 激素水平调查 绝经前对照显示血清雌二醇水平较低 肥胖女性与瘦女性相比，这或许可以解释风险降低的原因 这种癌症多发于年轻、肥胖的女性。 在年长的亚裔美国女性中， 然而，随着最近的肥胖和最近的肥胖，风险稳步增加 体重增加。 此外，肥胖的风险增加被证明是 在一项乳腺癌前瞻性研究中，与诊断时的年龄有关 65 岁或以上诊断出体重过重的女性的风险最高。 评论 体重与乳腺癌和子宫内膜癌风险的关系表明 避免体重增加和中央身体脂肪堆积 成年后可能会降低老年女性患这些癌症的风险。 脂肪百分比 饮食中的含量与乳腺癌风险增加无关，但 可能代表饮食模式的饮食习惯与 美国筛查人群的乳腺癌风险 高摄入量 研究发现，食用大豆（主要是豆腐）可降低罹患以下疾病的风险： 亚裔美国女性患乳腺癌。 来自妈妈们的信息 对病例和对照进行了分析，结果表明母乳喂养 婴儿时期与乳腺癌风险降低相关 美国年轻女性。 与从不饮酒的人相比，酒精摄入量较高 与白人和黑人患前列腺癌的风险增加有关 在一项大型病例对照研究中。 同样，乳腺疾病的风险也会增加 据观察，年轻女性患癌症的原因是大量饮酒， 最近的摄入量比之前的消耗量更重要 期间。