CARCINOGENIC EFFECTS OF THERAPEUTIC DRUGS

治疗药物的致癌作用

• 批准号: 4692273
• 负责人: R N HOOVER
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692273
• 关键词: alkylating agents; antihypertensive agents; breast neoplasms; cancer information system; cancer risk; cervix neoplasms; child (0-11); combination cancer therapy; cyclophosphamide; dosage; drug adverse effect; drug carcinogenesis; drug related neoplasm /cancer; drug screening /evaluation; endocrine disorder chemotherapy; estrogens; female antifertility drug; human age group; human mortality; human subject; iatrogenic disease; immunosuppressive; interview; isoniazid; kidney transplantation; leprosy; leukemia; longitudinal human study; lymphoma; menopause; methotrexate; microorganism disease chemotherapy; neoplasm /cancer chemotherapy; neoplasm /cancer genetics; neoplasm /cancer immunology; ovariectomy; ovary neoplasms; pediatric neoplasm /cancer; rheumatoid arthritis; sarcoma; skeletal disorder chemotherapy; tranquilizer; tuberculosis; uterus neoplasms

The purpose of this project is to study the long-term health effects of therapeutic drugs as they may relate to carcinogenicity. Cohort studies of exposed groups are conducted, as well as case-control studies of selected cancer sites which involve lifetime drug use histories. Emphasis has been on the evaluation of various hormonal preparations, immunosuppressive drugs, and cancer chemotherapeutic agents. No general effects of thyroid medications or antihypertensive medications have been seen on breast cancer risk, but menopausal estrogens seem to increase the risk of benign breast disease. Ovarian cancer risk was found to be increased by use of progestins, but decreased by menopausal estrogen use. Cervical cancer was elevated among users of oral contraceptives, particularly for long-term users. Alkylating agents used for treatment of cancer and some non-neoplastic conditions were found to be associated with large excess risks of leukemia that were apparently dose related. Future analyses are planned to evaluate the effects of estrognic preparations on a variety of female tumors and to assess, systematically, the role of adjuvant drug therapy among patients treated for a number of different cancers.

这个项目的目的是研究长期的健康影响。 治疗药物，因为它们可能与致癌有关。的队列研究 进行暴露人群，以及选定的病例对照研究 涉及终生吸毒史的癌症网站。重点一直是 关于各种激素制剂的评价，免疫抑制 药物和癌症化疗药物。甲状腺无全身影响 治疗乳腺癌的药物或降压药已经见诸报端。 风险，但更年期雌激素似乎增加了良性乳房的风险 疾病。卵巢癌的风险被发现通过使用 孕激素，但因绝经后雌激素的使用而减少。宫颈癌是 口服避孕药使用者，特别是长期服用避孕药的人 用户。用于治疗癌症和某些疾病的烷化剂 研究发现，非肿瘤性疾病与大量过量有关。 白血病的风险显然与剂量有关。未来的分析是 计划评估雌激素制剂对多种 并系统地评估辅助药物的作用 治疗多种不同癌症的患者。