HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDS

接触有机氯化合物对人类健康的影响

• 批准号: 2452855
• 负责人: M P LONGNECKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2452855
• 关键词: African American; breast neoplasms; clinical research; cryptorchidism; dichlorodiphenyltrichloroethane; embryo /fetus toxicology; environment related neoplasm /cancer; environmental toxicology; epidemiology; health surveys; human subject; perinatal; pesticide biological effect; sperm motility

A diverse group of halogenated organic compounds (e.g., DDT, PCBs [polychlorinated biphenyls]) commands special attention in public health because they are ubiquitous in the ecosystem and may be causing adverse human health effects at background levels of exposure. We will conduct or are conducting several studies of the human health effects of background exposure to organochlorines. We have in the field now a case-control study of serum p,p'-DDE (a metabolite of DDT) and PCB levels in relation to risk of breast cancer among African-American women in Los Angeles. Three hundred cases and 300 controls will be enrolled, and the data should be ready for analysis in 1999. We are also planning to look at health effects of organochlorine residues among participants in the Collaborative Perinatal Project, for whom a blood bank (mother's blood) is available. Projects to be evaluated, and carried out, if appropriate are: 1) an examination of mother's serum p,p'-DDE levels in relation to risk of hypospadias and cryptorchidism in male offspring, 2) in utero PCB exposure in relation to hyporeflexia/hypotonia at birth, and 3) mother's serum p,p'-DDE levels in relation to subsequent sperm counts and fertility of male offspring.

一组不同的卤代有机化合物（例如，滴滴涕、多氯联苯 [多氯联苯]）在公共卫生方面需要特别注意 因为它们在生态系统中无处不在， 在本底暴露水平下对人类健康的影响。 我们会进行 或者正在进行几项关于 有机氯的背景暴露。 我们现在在该领域进行了一项血清p，p '-DDE（a 滴滴涕代谢物）和多氯联苯水平与乳腺癌风险的关系 在洛杉矶的非裔美国女性中。 三百箱三百 将入组对照组，数据应准备好进行分析， 1999. 我们还计划研究有机氯残留物对健康的影响 在围产期合作项目的参与者中， 有血库（母亲的血）。 待评价的项目，以及 进行，如果适当的话：1）母亲的血清检查 p，p '-DDE水平与尿道下裂和隐睾症风险的关系 雄性后代，2）子宫内PCB暴露与 出生时反射减退/肌张力减退; 3）母亲血清p，p '-DDE水平 与随后的精子数量和雄性后代的生育能力有关。