STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

含酚酞缓泻剂使用与肿瘤的研究

• 批准号: 2452854
• 负责人: M P LONGNECKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2452854
• 关键词: cancer risk; clinical research; colon polyp; colorectal neoplasms; drug carcinogenesis; drug related neoplasm /cancer; human subject; interview; laxative; ovary neoplasms; phenols; questionnaires

Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein- containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. We have established collaborative agreements with the principal investigators for two ongoing case-control studies of risk factors for ovarian cancer. At our instigation, these investigators have inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. Each study will yield about 300 cases and 300 controls, and the data will be ready for analysis in 1999. Data collection for two case-control studies of risk factors for adenomatous colorectal polyps have been completed. Data on laxative use are available for both studies. We will examine laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives specifically will be explored after taking into account dietary and other risk factors for colorectal adenomas.

许多泻药中的一种成分酚酞， 最近在啮齿类动物中进行的2年喂养研究中， 国家毒理学计划（NTP）。 的3%左右 美国老年人使用含酚酞的泻药， 每天都 我们将研究酚酞- 含有泻药的使用有患卵巢癌和腺瘤的风险 结肠直肠息肉 我们已经与委托人签订了合作协议， 研究人员正在进行两项关于危险因素的病例对照研究， 卵巢癌 在我们的鼓动下，这些调查人员 在他们的调查表中增加了两页， 特定的含酚酞的泻药。 每项研究都会产生 大约300个病例和300个对照，数据将准备好进行分析。 1999年 两项危险因素病例对照研究的数据收集 结直肠腺瘤性息肉已经完成。 泻药使用数据 可用于两项研究。 我们将研究泻药的使用与 息肉的风险。 息肉与使用 所有的轻泻药和含酚酞的轻泻药特别地 在考虑饮食和其他风险因素后， 结直肠腺瘤