VALIDITY OF TOENAIL ELEMENT LEVELS AS A SURROGATE MEASURE OF EXPOSURE

脚趾甲元素水平作为暴露替代测量的有效性

• 批准号: 6162209
• 负责人: M P LONGNECKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162209
• 关键词: aluminum; chromium; clinical research; cobalt; copper; diagnosis; diagnosis design /evaluation; dietary calcium; dietary iron; dietary trace element; human subject; magnesium; manganese; mercury; metal metabolism; metal poisoning; metals; molybdenum; nutrition related tag; selenium; skin derivative; zinc

Summary of Work: For some elements, use of toenail levels as a surrogate measure of exposure may provide an estimate of exposure superior to that made on the basis of data from food frequency questionnaires, hair, blood levels, or other measures. Toenails reflect exposure over a longer period of time than do blood or urine measures, and are less likely to be influenced by contaminantion than hair. We hypothesize that toenail levels may provide a good measure of exposure for a group of elements (Ca, Mg, Fe, Zn, Cu, Mn, Se, Mo, Cr, Co, Hg, and Al), that has a purported link with chronic disease. Improved methods of asssessing exposure to these elements will facilitate studies of their adverse or beneficial health effects. Repeated samples of whole-diet homogenates and toenails were collected over a one-year period from 77 subjects. The element content of diet and toenail specimens is being determined by neutron activation analysis and graphite furnace atomic absorption. After the concentration of the trace elements in the toenails and diet specimens has been determined, we will examine how well the toenail level of each element reflects intake. We will also compare the estimates of intake based on nails with those obtained with a standard food-frequency questionnaire to see which is better.

工作总结：对于某些元素，使用脚趾甲水平作为 暴露替代测量可以提供暴露的估计 上级于根据食物频率数据所作的 调查问卷、头发、血液水平或其他测量。 脚趾甲反射 接触时间比血液或尿液测量的时间更长， 并且不像头发那样容易受到污染的影响。 我们 假设脚趾甲水平可以提供暴露的良好测量 对于一组元素（Ca、Mg、Fe、Zn、Cu、Mn、Se、Mo、Cr、Co、Hg和 Al），这与慢性疾病有着据称的联系。 的改进方法 评估这些元素的暴露程度将有助于研究它们的 不利或有益的健康影响。 收集全饮食匀浆和脚趾甲的重复样品 在一年的时间里，77名受试者。 膳食中元素含量和 脚趾甲标本正在确定中子活化分析， 石墨炉原子吸收法 在脚趾甲和饮食中微量元素的浓度 标本已确定，我们将检查如何以及趾甲水平 每个元素都反映了摄入量。 我们还将比较 基于指甲的摄入量与标准食物频率获得的摄入量 问卷调查，看看哪个更好。