VALIDITY OF TOENAIL ELEMENT LEVELS AS A SURROGATE MEASURE OF EXPOSURE

脚趾甲元素水平作为暴露替代测量的有效性

• 批准号: 2452853
• 负责人: M P LONGNECKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2452853
• 关键词: activation analysis; aluminum; atomic absorption spectrometry; chromium; chronic disease /disorder; clinical research; cobalt; copper; dietary calcium; dietary iron; dietary mineral; dietary trace element; human subject; magnesium; manganese; mercury; metal metabolism; metal poisoning; molybdenum; nutrition related tag; selenium; skin derivative; zinc

For some elements, use of toenail levels as a surrogate measure of exposure may provide an estimate of exposure superior to that made on the basis of data from food frequency questionnaires, hair, blood levels, or other measures. We hypothesize that this is the case for a group of elements (Ca, Mg, Fe, Zn, Cu, Mn, Se, Mo, Cr, Co, Hg, and Al), that has a purported link with chronic disease. Improved methods of assessing exposure to these elements will facilitate studies of their adverse or beneficial health effects. Repeated samples of whole-diet homogenates and toenails were collected over a one-year period from 77 subjects. The element content of diet and toenail specimens is being determined by neutron activation analysis and graphite furnace atomic absorption. After the concentration of the trace elements in the toenails and diet specimens has been determined, we will examine how well the toenail level of each element reflects intake.

对于某些元素，使用脚趾甲水平作为替代测量， 暴露可提供优于在所述装置上进行的暴露的估计的暴露的估计上级。 根据食物频率问卷、头发、血液水平或 其他措施。 我们假设这是一组 元素（Ca、Mg、Fe、Zn、Cu、Mn、Se、Mo、Cr、Co、Hg和Al）， 据称与慢性病有关 改进评估方法 接触这些元素将有助于研究它们的不利或 有益健康的影响。 收集全饮食匀浆和脚趾甲的重复样品 77名受试者在一年内进行了研究。 膳食中元素含量和 脚趾甲标本正在确定中子活化分析， 石墨炉原子吸收法 在脚趾甲和饮食中微量元素的浓度 标本已确定，我们将检查如何以及趾甲水平 每个元素都反映了摄入量。