VALIDITY OF TOENAIL ELEMENT LEVELS AS A SURROGATE MEASURE OF EXPOSURE

对于某些元素，使用脚趾甲水平作为替代测量， 暴露可提供优于在所述装置上进行的暴露的估计的暴露的估计上级。 根据食物频率问卷、头发、血液水平或 其他措施。 我们假设这是一组 元素（Ca、Mg、Fe、Zn、Cu、Mn、Se、Mo、Cr、Co、Hg和Al）， 据称与慢性病有关 改进评估方法 接触这些元素将有助于研究它们的不利或 有益健康的影响。 收集全饮食匀浆和脚趾甲的重复样品 在一年的时间里，77名受试者。 膳食中元素含量和 脚趾甲标本正在确定中子活化分析， 石墨炉原子吸收法 在脚趾甲和饮食中微量元素的浓度 标本已确定，我们将检查如何以及趾甲水平 每个元素都反映了摄入量。

For some elements, use of toenail levels as a surrogate measure of exposure may provide an estimate of exposure superior to that made on the basis of data from food frequency questionnaires, hair, blood levels, or other measures. We hypothesize that this is the case for a group of elements (Ca, Mg, Fe, Zn, Cu, Mn, Se, Mo, Cr, Co, Hg, and Al), that has a purported link with chronic disease. Improved methods of assessing exposure to these elements will facilitate studies of their adverse or beneficial health effects. Repeated samples of whole-diet homogenates and toenails were collected over a one-year period from 77 subjects. The element content of diet and toenail specimens is being determined by neutron activation analysis and graphite furnace atomic absorption. After the concentration of the trace elements in the toenails and diet specimens has been determined, we will examine how well the toenail level of each element reflects intake.