STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

工作总结：酚酞是许多泻药中的一种成分， 在两年的喂养研究中显示出明显的致癌活性 在最近由国家毒理学计划(NTP)完成的啮齿动物身上。 大约3%的美国老年人口使用含有酚酞的药物 每天服用泻药。我们将调查两国关系 使用含有酚酞的泻药有患卵巢癌和 人类的腺瘤性结直肠息肉。 我们已经与委托人建立了合作协议 正在进行的两项病例对照危险因素研究的调查人员 卵巢癌。在我们的怂恿下，这些调查人员插入了 在他们的调查问卷中添加了两页的内容，以确定使用 特定的含酚酞的泻药。每项研究都会得出 大约300个病例和300个对照，数据将准备好进行分析 在1999年。 艾滋病危险因素的两项病例对照研究资料收集 腺瘤性结直肠息肉已经完成。关于泻药使用的数据 均可用于这两项研究。我们已经检查了泻药的使用情况 在这些数据中与息肉风险的关系。息肉与疾病的关系 所有泻药和含有酚酞的泻药的使用是 在考虑到饮食和其他风险后具体探讨 结直肠腺瘤的影响因素。这两项研究的结果是 彼此不一致，但总体上几乎没有提供支持 含酚酞类泻药的使用与高血压风险的关系 息肉。

Summary of Work: Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. We have established collaborative agreements with the principal investigators for two ongoing case-control studies of risk factors for ovarian cancer. At our instigation, these investigators have inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. Each study will yield about 300 cases and 300 controls, and the data will be ready for analysis in 1999. Data collection for two case-control studies of risk factors for adenomatous colorectal polyps have been completed. Data on laxative use were available for both studies. We have examined laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives was specifically explored after taking into account dietary and other risk factors for colorectal adenomas. Results from the two studies were inconsistent with each other but overall offered little support for an association between phenolphthalein-containing laxative use and risk of polyps.