HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDS

接触有机氯化合物对人类健康的影响

• 批准号: 6162211
• 负责人: M P LONGNECKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162211
• 关键词: African American; clinical research; dichlorodiphenyltrichloroethane; embryo /fetus toxicology; environment related neoplasm /cancer; environmental toxicology; halobiphenyl /halotriphenyl compound; human subject; neoplasm /cancer epidemiology; outcomes research; pesticide biological effect

Summary of Work: A diverse group of halogenated organic compounds (e.g., DDT, PCBs [polychlorinated biphenyls]) commands special attention in public health because they are ubiquitous in the ecosystem and may be causing adverse human health effects at background levels of exposure. We will conduct or are conducting several studies of the human health effects of background exposure to organochlorines. We have in the field now a case-control study of serum p,p'-DDE (a metabolite of DDT) and PCB levels in relation to risk of breast cancer among African-American women in Los Angeles. Three hundred cases and 300 controls will be enrolled, and the data should be ready for analysis in 1999. We are also planning to look at health effects of organochlorine residues among participants in the Collaborative Perinatal Project, for whom a blood bank (mother's blood) is available. Projects to be carried out are: 1) an examination of mother's serum p,p'-DDE levels in relation to risk of hypospadias, cryptorchidism, and polythelia in male offspring, and 2) in utero PCB exposure in relation to neurodevelopmental outcomes.

工作总结：一组不同的卤代有机化合物（例如， 滴滴涕、多氯联苯[多氯联苯]）在 公共卫生，因为它们在生态系统中无处不在， 在本底接触水平下对人类健康造成不利影响。 我们将进行或正在进行几项关于人类健康的研究， 背景接触有机氯的影响。 我们现在在该领域进行了一项血清p，p '-DDE（a 滴滴涕代谢物）和多氯联苯水平与乳腺癌风险的关系 在洛杉矶的非裔美国女性中。 三百箱三百 将入组对照组，数据应准备好进行分析， 1999. 我们还计划研究有机氯残留物对健康的影响 在围产期合作项目的参与者中， 有血库（母亲的血）。 实施的项目 是：1）检查母亲的血清p，p '-DDE水平与 男性后代有尿道下裂、隐睾和多囊的风险， 和2）子宫内PCB暴露与神经发育结果的关系。