HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDS

工作概述：一组不同的卤代有机化合物(例如， 滴滴涕、多氯联苯)应特别注意 公共健康，因为它们在生态系统中无处不在，而且可能 在本底暴露水平下对人类健康造成不利影响。 我们将进行或正在进行几项关于人类健康的研究 背景接触有机氯的影响。 我们现在在现场进行了一项关于血清p，p‘-DDE(A)的病例对照研究 DDT代谢物)和多氯联苯水平与乳腺癌风险的关系 在洛杉矶的非裔美国女性中。三百箱和三百箱 将注册控件，数据应准备好用于分析 1999年。 我们还计划研究有机氯残留物对健康的影响 在合作围产期项目的参与者中， 提供血库(母亲的血液)。将开展的项目 1)检查母亲的血清p，p‘-DDE水平与 男性后代患上尿道下裂、隐睾症和前列腺增生症的风险， 2)子宫内接触多氯联苯与神经发育结局的关系。

Summary of Work: A diverse group of halogenated organic compounds (e.g., DDT, PCBs [polychlorinated biphenyls]) commands special attention in public health because they are ubiquitous in the ecosystem and may be causing adverse human health effects at background levels of exposure. We will conduct or are conducting several studies of the human health effects of background exposure to organochlorines. We have in the field now a case-control study of serum p,p'-DDE (a metabolite of DDT) and PCB levels in relation to risk of breast cancer among African-American women in Los Angeles. Three hundred cases and 300 controls will be enrolled, and the data should be ready for analysis in 1999. We are also planning to look at health effects of organochlorine residues among participants in the Collaborative Perinatal Project, for whom a blood bank (mother's blood) is available. Projects to be carried out are: 1) an examination of mother's serum p,p'-DDE levels in relation to risk of hypospadias, cryptorchidism, and polythelia in male offspring, and 2) in utero PCB exposure in relation to neurodevelopmental outcomes.