The elusive engram: What can infantile amnesia tell us about memory?

点击翻译按钮获取中文摘要

Revealing the 'engram' is one of the greatest challenges neuroscience has faced. Substantial advances have been made in elucidating the mechanisms underlying memories that last for a few hours or days but much less is known about the cellular and molecular processes that mediate memories across remote periods of time. An underutilised approach to this problem is to study forgetting. The infant rat is an ideal model as they typically display good memory for a day or two but forget after a week or more. That is, they exhibit a specific impairment in the maintenance of remote memories. This project aims to determine the molecular/cellular processes underlying infantile amnesia and is expected to provide unique insights into memory processes in general.