The elusive engram: What can infantile amnesia tell us about memory?

难以捉摸的印迹：婴儿失忆症能告诉我们关于记忆的什么信息？

• 批准号: DP150104835
• 负责人: Prof Rick Richardson
• 金额: $ 27.58万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104835
• 关键词: elusive; engram; What; infantile; amnesia

Revealing the 'engram' is one of the greatest challenges neuroscience has faced. Substantial advances have been made in elucidating the mechanisms underlying memories that last for a few hours or days but much less is known about the cellular and molecular processes that mediate memories across remote periods of time. An underutilised approach to this problem is to study forgetting. The infant rat is an ideal model as they typically display good memory for a day or two but forget after a week or more. That is, they exhibit a specific impairment in the maintenance of remote memories. This project aims to determine the molecular/cellular processes underlying infantile amnesia and is expected to provide unique insights into memory processes in general.

揭示“记忆痕迹”是神经科学面临的最大挑战之一。在阐明持续几小时或几天的记忆的机制方面已经取得了实质性的进展，但对于在遥远的时间段内介导记忆的细胞和分子过程知之甚少。一个未被充分利用的方法来解决这个问题是研究遗忘。幼鼠是一个理想的模型，因为它们通常在一两天内表现出良好的记忆力，但在一周或更长时间后就会忘记。也就是说，他们在维持远程记忆方面表现出特定的损伤。该项目旨在确定婴儿健忘症的分子/细胞过程，并有望为一般记忆过程提供独特的见解。