Developmental analysis of extinction of learned fear in rats

大鼠习得性恐惧消退的发育分析

• 批准号: DP0985554
• 负责人: Prof Rick Richardson
• 金额: $ 15.6万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985554
• 关键词: Developmental; analysis; extinction; learned; fear

This project aims to gain a better understanding of extinction (ie., loss) of learned fear in rats. Extinction is the process underlying exposure therapy, which is the most effective current treatment for anxiety disorders. Although most anxiety disorders are first diagnosed relatively early in life, we know very little about extinction of fear across development. However, recent findings have suggested that there are fundamental developmental differences in the extinction of fear, and the present project explores these differences in greater detail. By doing so, the project aims to increase our understanding of how fears can be inhibited, and may eventually lead to the development of age-appropriate treatments for anxiety disorders.

该项目旨在更好地了解灭绝（即，在老鼠中学习恐惧。消退是暴露疗法的基础过程，暴露疗法是目前治疗焦虑症最有效的方法。虽然大多数焦虑症在生命的早期就被诊断出来，但我们对恐惧在整个发展过程中的消失知之甚少。然而，最近的研究结果表明，在恐惧的消失方面存在根本的发展差异，本项目将更详细地探讨这些差异。通过这样做，该项目旨在增加我们对恐惧如何被抑制的理解，并可能最终导致开发适合年龄的焦虑症治疗方法。