BONE LOSS AND MUSCLE WEAKNESS AT THE HIP--ELDERLY BLACK AND WHITE SUBJECTS

髋部骨质流失和肌肉无力——老年黑人和白人受试者

• 批准号: 6234122
• 负责人: MUNRO PEACOCK
• 金额: $ 23.36万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6234122
• 关键词: African American; accidental falls; aging; bone density; bone imaging /visualization /scanning; bone metabolism; calcium metabolism; caucasian American; chemoprevention; clinical chemistry; clinical trials; dietary calcium; dietary supplements; disease /disorder proneness /risk; hip fractures; human old age (65+); human subject; human therapy evaluation; longitudinal human study; muscle strength; osteoporosis; photon absorptiometry; racial /ethnic difference; vitamin D; vitamin therapy

A trial of vitamin D and calcium on bone density and muscle strength at the hip in elderly women(n=336) and men(n= 140) will complete 3 years by June 1996. No blacks are in the trial. Bone density is higher in blacks which may explain their lower incidence of hip fracture but differences in other components of bone strength at the hip, including geometry, architecture and quality of bone and better muscle strength, lower incidence of falls or better absorption of the energy by soft tissues may also be involved. There are two goals: I. complete vitamin D and calcium trial at three years; II. study blacks to compare differences with whites in bone strength, fall frequency, soft tissue distribution and muscle strength at the hip and elucidate mechanisms responsible for differences. To achieve the first goal, extension of funding for the trial from Dec 1995 to June 1997 is requested. To achieve the second goal, two hypotheses will be tested: (1) the lower incidence of hip fractures in blacks is due to (a) greater bone strength at the hip which is due to higher bone density but also involves other components of bone strength, including bone architecture, geometry and quality; and (b)greater muscle mass and strength at the hip. (2) Bone density, architecture, geometry, and bone quality at the hip contribute independently, to predicting elderly black women and black and white men who have sustained a hip fracture. The first hypothesis will be tested by studying 350 black women and 150 black men over the age of 60. The variables that will be measured or recorded include: bone density, architecture, geometry and quality; mineral homeostasis and bone turnover; net calcium absorption and fractional radiocalcium absorption; frequency and type of fall; muscle strength; soft tissue distribution at the hip. The data in blacks will be compared with data already collected on white men and women. The second hypothesis will be tested by a case-control study of 50 black women, 50 black men and 50 white men who have had a hip fracture, using the 500 subjects studied in hypothesis (1) as black controls and 476 subjects in goal I. as white controls, and comparing the results in our published study of white women with hip fracture, the controls for which were also the women at base line in the trial of vitamin D and calcium. These studies will yield data on the factors related to hip fracture in blacks, and by comparing these with data already collected in whites from the same region, will allow the determinants of hip fracture in both populations to be identified.

维生素D和钙对骨密度和肌肉力量的影响 老年女性（n=336）和男性（n= 140）的髋关节将完成3年， 1996年6月审判中没有黑人。黑人的骨密度更高 这可能解释了他们髋部骨折的发生率较低， 髋关节骨强度的其他组成部分，包括几何形状， 骨骼的结构和质量以及更好的肌肉力量， 福尔斯的发生率或软组织对能量的更好吸收可 也参与其中。 有两个目标：一。三岁时完成维生素D和钙的试验 年;二。研究黑人与白人在骨骼方面的差异 力量，跌倒频率，软组织分布和肌肉力量， 髋关节和阐明机制负责的差异。实现 第一个目标是将试验的资金从1995年12月延长到6月， 1997年被要求。为了实现第二个目标，将提出两个假设。 测试：（1）黑人髋部骨折的发生率较低是由于（a） 髋部的骨强度更大，这是由于骨密度更高， 还涉及骨强度的其他成分，包括骨 （B）更大的肌肉质量， 臀部的力量(2)骨密度、结构、几何结构和骨 髋关节的质量独立地预测老年黑人 女性、黑人和白色男性髋部骨折。 第一个假设将通过研究350名黑人妇女和150名 60岁以上的黑人将被测量的变量或 记录包括：骨密度、结构、几何形状和质量; 矿物质稳态和骨转换;净钙吸收和 放射性钙吸收分数;跌倒频率和类型;肌肉 强度;髋关节软组织分布。黑色的数据将是 与已经收集的白色男性和女性的数据相比。 第二个假设将通过对50名黑人的病例对照研究进行检验。 女性，50名黑人男性和50名白色男性谁有髋骨骨折，使用 假设（1）中研究的500名受试者作为黑人对照， 目标I中的主题。作为白色对照，并比较我们的结果， 发表的一项关于白色髋部骨折妇女的研究， 也是维生素D和钙试验中处于基线的女性。 这些研究将产生与髋部骨折相关因素的数据， 黑人，并通过比较这些数据已经收集的白人， 相同的区域，将允许髋部骨折的决定因素， 人口有待识别。