GENETICS OF BONE LOSS AT THE HIP IN WOMEN

女性臀部骨质流失的遗传学

• 批准号: 7379056
• 负责人: MUNRO PEACOCK
• 金额: $ 3.23万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379056
• 关键词: GENETICS; BONE; LOSS; HIP; WOMEN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Heritability of bone mass at the hip is high, but heritability of bone loss at the hip has not been studied. Heritability of bone strength has been measured in 760 pairs of sisters, and a 10cM genome screen has identified several chromosomal loci influencing strength. The hypotheses that will be tested is that the rate of bone loss at the hip in women is genetically determined. This will be achieved by remeasuring hip bone mass in 500 pairs of sisters that had participated in the GCRC Protocol 578 a minimum of 5 years ago. Using the Lunar DPX-L dual X-ray absorptiometry (DXA) the following sites will be measured: the right femoral neck, trochanter and wards, lumbar vertebrae L2 to L4 and total body. Radiographs of the lower pelvis with upper femura in 15 degree internal rotation will be taken on standard X-ray equipment. All structural measurements will be made on the same hip using a digital caliper. Volumetric Quantitative Computed Tomograph (CT) will be performed according to an established protocol. Fasting blood and urine will be collected for measurement of calcium regulating hormones and bone turnover markers. Anthropometrics will be collected on dedicated instruments, total body lean and fat are measured by DXA. Questionnaires will be administered which include personal, family and medical history, gynecological history, medication history, smoking, physical activity and diet. All questionnaires have been verified and have been in use over the last five years in the current sister study.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。髋部骨量的遗传率较高，但髋部骨质流失的遗传率尚未得到研究。在760对姐妹中测量了骨骼强度的遗传力，并通过10cM基因组筛选确定了几个影响强度的染色体位点。将被测试的假设是，女性臀部骨质流失的速度是由基因决定的。这将通过重新测量至少5年前参加GCRC方案578的500对姐妹的髋骨质量来实现。使用Lunar DPX-L双x线吸收仪（DXA）测量以下部位：右股骨颈、股骨粗隆和椎体、腰椎L2至L4和全身。在标准x线设备上拍摄骨盆下部和股骨上部15度内旋的x线片。所有的结构测量都将使用数字卡尺在同一髋部进行。容积定量计算机断层扫描（CT）将按照既定的方案进行。将收集空腹血液和尿液，用于测量钙调节激素和骨转换标志物。人体测量将在专用仪器上收集，全身瘦和脂肪由DXA测量。调查问卷将包括个人、家庭和病史、妇科病史、用药史、吸烟、体育活动和饮食。所有的调查问卷都已经过验证，并在过去五年中一直在当前的姊妹研究中使用。