GENETICS OF BONE STRENGTH IN MEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 与年龄相关的骨质疏松性骨折，特别是髋部骨折，是美国和世界范围内的一个主要健康问题。与年龄相关的骨强度下降是骨质疏松性骨折的主要危险因素。骨强度的成分是高度可遗传的，在我们使用绝经前姐妹配对进行的研究中，我们发现了与骨量和骨结构的几个测量指标的关联。关于测量男性骨骼强度的遗传力研究非常有限。此外，对老鼠的研究表明，性别特异性基因可能是导致男性和女性骨骼强度差异的原因。这项研究将检验的假设是，男性的骨量、骨结构、骨质量和骨转换具有基因决定的成分，其大小与我们在女性中确定的相似。然而，虽然许多基因座在两性中是相同的，但某些基因座将是性别特有的。双X射线骨密度仪测量的骨骼部位是右股骨颈、粗隆和Ward、腰椎L2至L4和全身。在标准X光设备上拍摄股骨上端旋转15度的骨盆下段的X光片。所有的结构测量都是在右侧髋关节(与DXA测量的相同)上使用数字卡尺进行的。采集空腹血和尿液，测定钙调节激素和骨转换生化标志物。人体测量学是在专用仪器上测量的；整体瘦身和脂肪是由DXA测量的。这些问卷包括个人、家庭和病史、服药史、吸烟、体力活动和饮食问卷。所有调查问卷都经过核实，并在过去五年中在GCRC第578号议定书中使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Age-related oateoporotic fracture, particularly hip fracture, is a major health problem in the United States and worldwide. Age-related decrease in bone strength is a major risk factor for osteoporotic fracture. Components of bone strength are highly heritable, and in our studies using premenopausal sister pairs, we have detected linkage to several measures of both bone mass and bone structure. Heritability studies on measure of bone strength in men are very limited. Furthermore, studies in mice suggest that sex specific genes may underlie differences in bone strength between men and women. The hypothesis that will be tested in this study is that in men bone mass, bone structure , bone quality and bone turnover have components that are genetically determined and are similar in magnitude to those we have established in women. However, while many loci will be the same in both sexes, certain loci will be sex specific. The skeletal sites that are being measured by dual X-ray absorptiometry are right femoral neck, trochanter and wards, lumbar vertebrae L2 to L4 and total body. Radiographs of the lower pelvis with upper femura in 15 degrees internal rotation are taken on standard X-ray equipment. All structural measurements are made on the right hip (the same measured by DXA) using a digital caliper. Fasting blood and urine will be collected for measurement of calcium regulating hormones and biochemical markers of bone turnover. Anthropometrics are measured on dedicated instruments; total body lean and fat are measured by DXA. The questionnaires include personal, family and medical history, medication history, smoking, physical activity and dietary questionnaires. All questionnaires have been verified and have been use over the last five years in GCRC Protocol 578.