THE EFFECT OF GENISTEIN AND ISOFLAVONE METABOLITES ON CALCIUM ABSORPTION AND

染料木黄酮和异黄酮代谢物对钙吸收和吸收的影响

• 批准号: 7717567
• 负责人: MUNRO PEACOCK
• 金额: $ 0.01万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717567
• 关键词: Biochemical Markers; Bone Density; Bone Resorption; Botanicals; Calcium; Computer Retrieval of Information on Scientific Projects Database; Diet; Dose; Effectiveness; Estrogen Replacement Therapy; Estrogens; Excretory function; Funding; Genistein; Grant; Individual; Institution; Invasive; Isoflavones; Isotopes; Kinetics; Label; Life; Marketing; Measures; Monitor; Osteoporosis; Postmenopause; Research; Research Personnel; Resources; Skeleton; Source; United States National Institutes of Health; Urine; Woman; absorption; accelerator mass spectrometry; bone; bone health; bone turnover; dosage; equol; innovation; prevent; response; risedronate sodium; soy protein isolate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several types of botanical products containing isoflavones are being marketed as an alternative to estrogen replacement therapy to prevent osteoporosis in postmenopausal women. Estrogen suppresses bone resorption and may increase calcium absorption. Efficacy of isoflavones on bone health has mixed results which may depend on the dose and interaction of isoflavones and the ability of individuals to produce equal. This project will determine the dose response of effect of genistein and the interaction with other soy isoflavones on calcium absorption and bone resorption in postmenopausal women who are equol vs. nonequol producers. We will use 41Ca, a long-lived isotope, to label the skeleton and an Accelerator Mass Spectrometry (AMS) to monitor perturbations by diet. This innovative approach to study bone resorption is a direct measure of bone resorption in contrast to biochemical markers of bone turnover and traditional calcium kinetics, rapid compared to studying changes in bone density, and not as invasive as bone histomorphometry. We are able to systematically determine the effect of various types and dosages of isoflavone-containing botanical products sequentially in the same postmenopausal women for their effectiveness in suppressing bone resorption by measuring changes in 41Ca excretion in the urine. As a positive control the effect of isoflavones will be compared to Actonel , a common osteoporosis treatment therapy.

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