GENETICS OF BONE LOSS AT THE HIP IN WOMEN
GENETICS OF BONE LOSS AT THE HIP IN WOMEN
批准号:
7606377
负责人:
MUNRO PEACOCK
金额:
$2.24万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-12-01 至 2007-11-30
关键词:
BloodCalciumComputer Retrieval of Information on Scientific Projects DatabaseDietEquipmentFamily history ofFastingFatty acid glycerol estersFundingGeneticGenomeGrantHeritabilityHip region structureHormonesInstitutionMeasurementMeasuresNeckPelvisPharmaceutical PreparationsPhysical activityProtocols documentationQuestionnairesRateRecording of previous eventsResearchResearch PersonnelResourcesRoentgen RaysRotationSisterSiteSmoking HistorySourceStandards of Weights and MeasuresTestingTrochantersUnited States National Institutes of HealthUrineWomanbonebone lossbone strengthbone turnoverdigitalhip boneinstrumentlumbar vertebra bone structureward
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Heritability of bone mass at the hip is high, but heritability of bone loss at the hip has not been studied. Heritability of bone strength has been measured in 760 pairs of sisters, and a 10cM genome screen has identified several chromosomal loci influencing strength. The hypotheses that will be tested is that the rate of bone loss at the hip in women is genetically determined. This will be achieved by remeasuring hip bone mass in 500 pairs of sisters that had participated in the GCRC Protocol 578 a minimum of 5 years ago. Using the Lunar DPX-L dual X-ray absorptiometry (DXA) the following sites will be measured: the right femoral neck, trochanter and wards, lumbar vertebrae L2 to L4 and total body. Radiographs of the lower pelvis with upper femura in 15 degree internal rotation will be taken on standard X-ray equipment. All structural measurements will be made on the same hip using a digital caliper. Volumetric Quantitative Computed Topograph (CT) will be performed according to an established protocol. Fasting blood and urine will be collected for measurement of calcium regulating hormones and bone turnover markers. Anthropometrics will be collected on dedicated instruments, total body lean and fat are measured by DXA.
Questionnaires will be administered which include personal, family and medical history, gynecological history, medication history, smoking, physical activity and diet. All questionnaires have been verified and have been in use over the last five years in the current sister study.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
THE EFFECT OF GENISTEIN AND ISOFLAVONE METABOLITES ON CALCIUM ABSORPTION AND
-
批准号:7717567
-
项目类别:
-
资助金额:$0.01万
-
财政年份:2007
-
负责人:MUNRO PEACOCK
-
依托单位:
GENETICS OF BONE STRENGTH IN MEN
-
批准号:7606376
-
项目类别:
-
资助金额:$3.41万
-
财政年份:2006
-
负责人:MUNRO PEACOCK
-
依托单位:
THE EFFECT OF GENISTEIN AND ISOFLAVONE METABOLITES ON CALCIUM ABSORPTION AND
-
批准号:7606470
-
项目类别:
-
资助金额:$0.17万
-
财政年份:2006
-
负责人:MUNRO PEACOCK
-
依托单位:
GENETICS OF BONE LOSS AT THE HIP IN WOMEN
-
批准号:7205753
-
项目类别:
-
资助金额:$2.34万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
GENETICS OF BONE STRENGTH IN MEN
-
批准号:7379055
-
项目类别:
-
资助金额:$5.45万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
GENETICS OF BONE LOSS AT THE HIP IN WOMEN
-
批准号:7379056
-
项目类别:
-
资助金额:$3.23万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
A RANDOMIZED DOUBLE-BLIND STUDY TO EVALUATE AMG 162 IN THE PREVENTION OF
-
批准号:7379139
-
项目类别:
-
资助金额:$0.14万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
GENETICS OF BONE LOSS AND BONE STRENGTH IN WOMEN & MEN
-
批准号:7020553
-
项目类别:
-
资助金额:$45.5万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
GENETICS OF BONE STRENGTH IN MEN
-
批准号:7205752
-
项目类别:
-
资助金额:$6.56万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
DNA STORAGE AND ANALYSIS IN METABOLIC BONE DISEASE
-
批准号:7205738
-
项目类别:
-
资助金额:$0.02万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
A RANDOMIZED DOUBLE-BLIND STUDY TO EVALUATE AMG 162 IN THE PREVENTION OF
-
批准号:7205849
-
项目类别:
-
资助金额:$0.02万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
AMG 162 IN THE TREATMENT OF POSTMENOPAUSAL WOMEN WITH LOW BONE MINERAL DENSITY
-
批准号:7379071
-
项目类别:
-
资助金额:$0.02万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
CALCIUM METABOLISM IN ASIAN ADOLESCENTS
-
批准号:7379163
-
项目类别:
-
资助金额:$1.94万
-
财政年份:2005
-
负责人:MUNRO PEACOCK
-
依托单位:
Genetics of Bone Strength in men
-
批准号:7045146
-
项目类别:
-
资助金额:$7.68万
-
财政年份:2003
-
负责人:MUNRO PEACOCK
-
依托单位:
Genetics of bone loss at the hip in women
-
批准号:7045147
-
项目类别:
-
资助金额:$3.39万
-
财政年份:2003
-
负责人:MUNRO PEACOCK
-
依托单位:
GENETICS OF BONE LOSS AND BONE STRENGTH IN MEN AND WOMEN
-
批准号:6399654
-
项目类别:
-
资助金额:$4.9万
-
财政年份:2000
-
负责人:MUNRO PEACOCK
-
依托单位:
BONE LOSS AND MUSCLE WEAKNESS AT THE HIP--ELDERLY BLACK AND WHITE SUBJECTS
-
批准号:6200959
-
项目类别:
-
资助金额:$24.16万
-
财政年份:1999
-
负责人:MUNRO PEACOCK
-
依托单位:
CORE--CALCIUM ABSORPTION AND BIOCHEMISTRY
-
批准号:6200962
-
项目类别:
-
资助金额:$24.16万
-
财政年份:1999
-
负责人:MUNRO PEACOCK
-
依托单位:
HERITABILITY & GENETIC MARKERS OF BONE STRENGTH AND BONE TURNOVER
-
批准号:6117771
-
项目类别:
-
资助金额:$1.7万
-
财政年份:1998
-
负责人:MUNRO PEACOCK
-
依托单位:
SALMON CALCITONIN NASAL SPRAY IN THE PREVENTION OF OSTEOPOROTIC FRACTURE
-
批准号:6117747
-
项目类别:
-
资助金额:$1.7万
-
财政年份:1998
-
负责人:MUNRO PEACOCK
-
依托单位:
国内基金
海外基金
Calcium/NFAT/GLUT3通路调控糖酵解代谢在CAR-T细胞耗竭中的作用和机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:张明明
-
依托单位:
miR-30调控Calcium/Calcineurin通路在慢性肾脏病心肌保护中的作用
-
批准号:81670699
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2016
-
负责人:郑春霞
-
依托单位:
水稻OsCAS(Calcium-sensing Receptor)基因的功能分析
-
批准号:30900771
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2009
-
负责人:赵昕
-
依托单位: