FASEB CONFERENCE--RENAL HEMODYNAMICS/VASCULAR BIOLOGY

FASEB 会议--肾血流动力学/血管生物学

• 批准号: 2597002
• 负责人: John E Hall
• 金额: $ 2.1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2597002
• 关键词: hemodynamics; kidney function; meeting /conference /symposium; neuroregulation; travel

DESCRIPTION (adapted from the application) This application requests partial funding for a FASEB Summer Research Conference on Renal Hemodynamics: Integration of Endothelial, Epithelial and Vascular Control Mechanisms to be held on June 27-July 2, 1998 at Vermont Academy, Saxton's River, VT under the auspices of the Federation of American Societies for Experimental Biology (FASEB). The conference will assemble investigators from multiple disciplines who use diverse approaches (cell and molecular to integrative whole animal) to understand the regulation of the renal circulation. The format consists of nine major sessions, five morning an four evening sessions, with daily pre-dinner poster discussion sessions. There will be approximately 75 invited speakers who, after brief overview by the session chairs, will address current unresolved issues and recent ongoing research directed at their resolution. Each speaker has been asked to present their most recent unpublished work and to focus on identifying the major unanswered questions in the field and the experimental approaches to answering these questions. Each presentation is followed by discussion and there is a large amount of time available in the afternoons for informal discussions amon the participants. Previous conferences in 1989, 1992 and 1995 were very successful and conducive to the exchange of ideas among the participants. Give the rapid developments in this important area, we expect that the 1998 conference will foster further exchange and interaction among investigators working at different levels within this complex integrated system. To stimulat future investigative interests in the area, attempts have been made to identif young investigators from active, contributing laboratories as speakers (including fellows and trainees) with special attention given to minorities an women. The topics that will be covered are: 1) the molecular and cellular physiology of the glomerulus and vascular smooth muscle (growth and remodeling of the vascular wall, extracellular matrix regulation, growth factors, signal transduction pathways, ion channels, cell stretch and shear), 2) endothelial/autacoid control of tubular and vascular function (shear stress an gene expression, the vascular cytoskeleton, and the role of the endothelium in normal control of tubular and vascular function as well as in renal disease), 3) interactions of neurohumoral and autacoid mechanisms and control of tubular and vascular function (thromboxane, arachidonic acid products, receptor gene expression, and ontogeny of control mechanisms), 4) tubular and vascular interactions in control of glomerular filtration (tubuloglomerular feedback an functional characteristics of macula densa cells), 5) tubular and vascular functions of the renin-angiotensin system (molecular biology of angiotensin receptors, renin synthesis and secretion, angiotensin signaling pathways, role in nephrogenesis and vascular development, and interactions with other autacoids/hormones, 6) the renal medullary circulation and pressure natriuresis, 7) physiology and pathophysiology of the renal circulation (including molecular and genetic approaches to renal vascular development and disease.

描述（改编自应用程序） 该申请要求部分资金用于FASEB夏季研究 肾血流动力学会议：内皮细胞、上皮细胞 将于1998年6月27日至7月2日 佛蒙特州萨克斯顿河佛蒙特学院，由联邦赞助 美国实验生物学学会（American Societies for Experimental Biology，FASEB） 会议将 集合来自多个学科的研究人员，他们使用不同的方法 (cell从分子到完整的动物）来理解 调节肾循环。 该格式包括九个主要 会议，五个上午和四个晚上的会议，每天餐前 海报讨论会。 将有大约75位受邀演讲者 在会议主席进行简短概述后，他将讨论当前的问题 未解决的问题和最近正在进行的旨在解决这些问题的研究。 每位演讲者都被要求介绍他们最近未发表的作品 并重点确定该领域尚未回答的主要问题， 用实验方法来回答这些问题。 每个呈现 接下来是讨论，有大量的时间可以在 下午，与会者进行非正式讨论。 先前 1989年、1992年和1995年的会议非常成功， 与会者交流思想。 鉴于 在这一重要领域，我们期望1998年的会议将进一步促进 各级调查人员之间的交流和互动 在这个复杂的系统中。 以激励未来的调查 在该地区的利益，试图确定年轻的 来自活跃的、有贡献的实验室的研究人员作为演讲者（包括 研究员和受训人员），并特别关注少数群体和妇女。 将涵盖的主题是：1）分子和细胞 肾小球和血管平滑肌的生理学（生长和 血管壁重塑，细胞外基质调节，生长 因子、信号转导途径、离子通道、细胞伸展和 剪切），2）肾小管和血管功能的内皮/自体素控制 （切应力基因表达，血管细胞骨架，和作用， 正常控制肾小管和血管功能的内皮细胞 如在肾脏疾病中），3）神经体液和自泌激素的相互作用 肾小管和血管功能的机制和控制（血栓烷， 花生四烯酸产物、受体基因表达和对照个体发育 机制），4）控制肾小球的肾小管和血管相互作用 过滤（管球反馈的功能特征， 致密斑细胞），5）肾小管和血管功能的 血管紧张素受体分子生物学 合成与分泌，血管紧张素信号通路，作用 肾发生和血管发育，以及与其他 类固醇/激素，6）肾髓循环和压力 尿钠排泄，7）肾循环的生理学和病理生理学 （包括肾血管发育的分子和遗传方法） 和疾病