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ABSORBED DOSE MEASURMENTS USING POLYMER/GEL CHAMBERS

使用聚合物/凝胶室测量吸收剂量

基本信息

批准号：
2436523
负责人：
MAREK J MARYANSKI
金额：
$ 9.43万
依托单位：
MGS RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-06-01 至 1999-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2436523
关键词：
biomedical equipment development biotechnology gel ionization method development nuclear magnetic resonance spectroscopy particle beam polymers radiation dosage

项目摘要

DESCRIPTION: The investigators propose to test the feasibility of developing a gel-based dosimeter with tissue mimicking properties that would be read by change in NMR or optical signal due to an X-ray dose- related polymerization, as further described by their abstract: "This proposal aims to develop tissue-equivalent polymer-gel chambers as substitutes for conventional ionization chambers, and to establish the feasibility of designing simple photometers or bench-top NMR relaxometers to measure radiation doses accurately. X-ray, electron and heavy-charged-particle beams are routinely calibrated with ionization chambers, which present a complex theoretical problem: how to convert the electrical charge from air ionization to the energy absorbed per mass of tissue. The calibration of radiations above 1 MeV requires that the ionization chamber first be calibrated for 60Co gamma rays at a national or regional laboratory. Subsequently, this calibration factor and as many as a dozen other chamber-and radiation-dependent parameters are applied to obtain the tissue dose. The uncertainty in the tissue- dose determination is + 3%. The polymer-gel dosimeter is tissue (muscle) equivalent so that, after calibration at one energy, the dose-to-muscle at another energy is obtained without complex corrections. The overall goal of the proposed research is to demonstrate that small polymer-gel chambers can be reliably constructed and used to calibrate radiation bemas, and to design the instrumentation (optical or NMR relaxation measuring devices) needed to provide a novel, clinical dosimetry system." PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：研究人员建议测试的可行性，开发具有组织模拟特性的凝胶基剂量计，将通过NMR或光学信号的变化来读取，这是由于X射线剂量引起的- 相关的聚合，如他们的摘要进一步描述的： “这项提案旨在开发组织等效的聚合物凝胶腔室作为传统电离室的替代品，并建立设计简单光度计或台式NMR的可行性弛豫计来精确测量辐射剂量。 X射线、电子和重带电粒子束通常用电离来校准商会，这提出了一个复杂的理论问题：如何转换从空气电离的电荷到每单位吸收的能量一团组织 1 MeV以上辐射的校准要求：电离室首先被校准为60 Co伽马射线，国家或地区实验室。随后，该校准因子以及其他十几个与电离室和辐射有关的参数以获得组织剂量。组织中的不确定性- 剂量测定为± 3%。聚合物凝胶剂量计是组织（肌肉）因此，在一个能量下校准后，在另一个能量下，无需复杂的校正即可获得。整体这项研究的目的是证明小的聚合物凝胶可以可靠地构造电离室，并将其用于校准辐射 bemas，并设计仪器（光学或NMR弛豫测量装置），以提供一种新颖的临床剂量测定方法系统" 拟议商业应用：不可用

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Chiral CE separation of dopamine-derived neurotoxins.

多巴胺衍生神经毒素的手性毛细管电泳分离。

DOI：
10.2116/analsci.21.115
发表时间：
2005
期刊：
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
影响因子：
0
作者：
Quan,Zhe;Song,Yaru;Peters,Gladys;Shenwu,Ming;Sheng,Yinghong;Hwang,Huey-Min;Liu,Yi-Ming
通讯作者：
Liu,Yi-Ming

Synthesis and structure-activity correlation studies of metal complexes of alpha-N-heterocyclic carboxaldehyde thiosemicarbazones in Shewanella oneidensis.

希瓦氏菌α-N-杂环甲醛缩氨基硫脲金属配合物的合成及构效相关研究。