LASER MICRO-BEAM CT SCANNING OF DOSIMETRY GELS

剂量测定凝胶的激光微束 CT 扫描

• 批准号: 6298637
• 负责人: MAREK J MARYANSKI
• 金额: $ 58.82万
• 依托单位: MGS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-15 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298637
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; computed axial tomography; gel; image enhancement; lasers; nuclear magnetic resonance spectroscopy; phantom model; radiation dosage; radionuclide imaging /scanning

DESCRIPTION (Applicant's abstract verbatim): The long-term goal of this project is to provide radiation therapy departments and equipment vendors with a unique tool for accurate, fast and fully three-dimensional characterization of small radiotherapy fields, whether external beams or brachytherapy, with isotropic spatial resolution on the order of 100 microns. Our system is based on laser micro-beam CT scanning of tissue-equivalent dosimeter gels that change their optical properties in proportion to the absorbed dose. In Phase I we have designed, built and thoroughly tested two different prototypes of the micro-scanner, and have successfully proved the feasibility of our idea. In Phase II we will complete the research and development of the micro-scanner and will engineer various gel phantoms for micro-scanning. We will field-test our system in a clinical environment, and perform thorough dosimetry studies of various small fields and brachytherapy sources of clinical importance, comparing our technique with radiochromic film measurements. In Phase III we will license out the manufacture of our micro-scanner, and concentrate our efforts on manufacturing various gel dosimetry phantoms for high-resolution 3D dosimetry. We believe that our system will find widespread use in QA procedures and in patient treatment verification, wherever very high dose gradients are present in the treatment plan. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（申请人的摘要逐字）：该项目的长期目标 是为放射治疗部门和设备供应商提供一个独特的 用于精确、快速和完全三维表征小尺寸 放射治疗野，无论是外部射束还是近距离放射治疗，具有各向同性 空间分辨率在100微米的数量级。我们的系统是基于激光 微束CT扫描的组织等效剂量计凝胶，改变其 光学性质与吸收剂量成比例。在第一阶段， 设计，建造和彻底测试了两种不同的原型， 微型扫描仪，并成功地证明了我们的想法的可行性。在 第二阶段我们将完成微型扫描仪的研发， 将为显微扫描设计各种凝胶体模。我们将实地测试我们的 系统在临床环境中，并进行彻底的剂量测定研究， 临床重要的各种小射野和近距离放射治疗源， 将我们的技术与辐射变色胶片测量进行比较。在第三阶段，我们 将授权生产我们的微型扫描仪，并集中我们的 致力于制造用于高分辨率3D的各种凝胶剂量测定体模 剂量测定法我们相信我们的系统将在质量保证程序中得到广泛应用 以及在患者治疗验证中，无论在什么情况下， 在治疗计划中。 拟定商业应用： 不可用