2-Phase Nanogels for Quantitative 3D Radiation Dosimetry

用于定量 3D 辐射剂量测定的 2 相纳米凝胶

• 批准号: 6694981
• 负责人: MAREK J MARYANSKI
• 金额: $ 24.86万
• 依托单位: MGS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694981
• 关键词: free radical scavengers; gel; hydropathy; micelles; monomer; nanotechnology; polymerization; radiation dosage; surfactant; technology /technique development

MGS Research has pioneered the development of polymer gel dosimeters, using both MRI and optical CT scanning. Our goal in Phase I will be to prove the feasibility of an innovative two-phase nanostructured polymer gel for quantitative 3D radiation dosimetry. The new gel structure can be described as a "single-hit 3D photon counter" that can be expected to be linear with dose and to be dose-rate independent. Moreover, it will be characterized by greater reproducibility, accuracy and stability of the dose response. As a result, the nanostructured polymer gels will be more suitable than the existing single-phase gels for the quantitative 3D radiation dosimetry and high-precision quality assurance, which are very much needed in intensity modulated and 3D conformal radiation therapy.

MGS Research率先开发了聚合物凝胶剂量计，使用MRI和光学CT扫描。我们在第一阶段的目标是证明一种创新的两相纳米结构聚合物凝胶用于定量3D辐射剂量测定的可行性。 新的凝胶结构可以被描述为“单次击中3D光子计数器”，其可以预期与剂量成线性并且与剂量率无关。此外，其特征在于剂量响应的更高再现性、准确性和稳定性。 因此，纳米结构的聚合物凝胶将比现有的单相凝胶更适合于定量的三维辐射剂量测定和高精度的质量保证，这是非常需要的强度调制和三维适形放射治疗。