POLYMER GEL FOR CLINICAL 3D RADIATION DOSIMETRY BY MRI

本项目旨在开发一种新型的组织等效凝胶剂量仪。 电离辐射，它能够产生高度分辨率和 利用磁场法获得三维剂量分布的精确数据 磁共振成像(MRI)。剂量反应机制依赖于 凝胶中水的质子核磁共振弛豫增强 辐射吸收，其中分散在凝胶中的丙烯酸共聚单体是 聚合的。10Gy量级的剂量可以用空间辐射测量 使用临床磁共振成像设备的分辨率低于1 mm。此外, 透明凝胶的光学混浊度随吸收剂量的增加而增大 因为共聚物从水中沉淀出来，因此剂量 分布也可以用光学方式可视化。凝胶会找到 在放射治疗实践中广泛使用，用于三维测量 同质和拟人模体，计算机化的确认 治疗计划和质量保证程序。阶段性目标 我将设计和评估一项方便和廉价的协议 聚合物凝胶剂量仪样机的研制及其应用 剂量的稳定性和重复性以及空间一致性- 回应。这些研究将为...的发展奠定基础 更有效的聚合物凝胶在第二阶段。

This project aims to develop a novel, tissue-equivalent gel-dosimeter of ionizing radiation, which is capable of producing highly-resolved and accurate data on three dimensional dose distributions using magnetic resonance imaging (MRI). The dose-response mechanism relies on the enhancement of the proton NMR relaxation of water in the gel at the site of radiation absorption, where acrylic comonomers dispersed in the gel are polymerized. Doses of the order of 10 Gy can be measured with a spatial resolution less than lmm using clinical MR imaging equipment. In addition, the optical turbidity of the transparent gel increases with absorbed dose because the copolymer precipitates from water, and thus the dose distribution can also be optically visualized. The gel will find widespread use in radiation therapy practice, for 3D measurements in homogeneous and anthropomorphic phantoms, confirmation of computerized treatment planning and in quality assurance procedures. The goals of Phase I are to devise and evaluate a protocol for convenient and inexpensive preparation of a prototype polymer-gel dosimeter, and to demonstrate its stability and reproducibility as well as spatial uniformity of the dose- response. These studies will prepare the ground for the development of more efficient polymer-gels in Phase II.