QA OF ENDOVASCULAR RADIOACTIVE SOURCES BY OPTICAL CT

通过光学 CT 进行血管内放射源的质量保证

• 批准号: 2540822
• 负责人: MAREK J MARYANSKI
• 金额: $ 11.5万
• 依托单位: MGS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-15 至 1998-12-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2540822
• 关键词: biomedical equipment development; clinical biomedical equipment; computed axial tomography; coronary artery; image enhancement; nuclear magnetic resonance spectroscopy; radiation dosage; radionuclide imaging /scanning; restenosis

It has recently been demonstrated that the restenosis of coronary arteries following balloon angioplasty can be prevented by irradiation of the previously stenotic area using small radioactive sources attached to the ends of catheters. Whether beta or gamma emitters, the biologically-significant doses delivered by these sources do not extend beyond several millimeters, and conventional methods of dosimetry are both impractical and lack the spatial resolution necessary to fully characterize their dose distributions. This project aims to provide a unique solution to the problem of quick and thorough characterization of these sources. A microscopic tomographic optical laser scanner will be developed, which will measure, with spatial resolution of 100 microns per pixel, full 3D dose distributions produced by these sources when inserted directly in the BANG polymer-gel dosimeter - our proprietary tissue-equivalent gel material whose optical attenuation increases linearly with absorbed radiation dose. In Phase I the feasibility will be demonstrated by building a simple prototype scanner and analyzing its performance, including spatial resolution and uniformity, accuracy, and minimum time needed for adequate data acquisition. Data obtained from this scanner will be compared with data generated by currently used techniques such as thermoluminescent crystals or radiochromic film, and with NMR microimaging. PROPOSED COMMERCIAL APPLICATION It is estimated that initially about 10,000 sources will need a thorough QA in the US. If each QA gel is priced at dollars 50, the sales of gels alone would produce dollars 500,00 annual revenue. About 25 micro scanners will be sold per year at a dollars 10,000 per scanner, yielding an additional dollars 250,000 annual revenue.

最近研究表明，冠状动脉再狭窄 球囊血管成形术后的动脉可以通过照射来预防 使用小的放射源， 到导管的末端。 无论是β还是γ发射体， 这些放射源释放的具有生物学意义的剂量 超过几毫米，常规的剂量测定方法 这既不切实际，又缺乏充分 描述其剂量分布。 该项目旨在提供一个 快速和彻底表征问题的独特解决方案 这些来源。 显微断层光学激光扫描仪将 该系统将以100微米的空间分辨率进行测量 每像素，这些源产生的全3D剂量分布， 直接插入到BANG聚合物凝胶剂量计中-我们的专利 光衰减增加的组织等效凝胶材料 与吸收的辐射剂量呈线性关系。 在第一阶段，可行性将 通过构建一个简单的原型扫描仪并分析其 性能，包括空间分辨率和均匀性，准确性， 充分采集数据所需的最短时间。 获得的数据 该扫描仪将与当前使用的 技术，如热致发光晶体或辐射变色膜，以及 核磁共振显微成像 建议的商业应用 据估计，最初约有10，000个来源将需要一个彻底的 在美国QA。 如果每个质量保证凝胶的价格为50美元， 光是这一项每年就能带来五十万美元的收入。 约25微米 扫描仪将以每台1万美元的价格出售， 额外的25万美元的年收入。