AUTOMATED VERIFICATION SYSTEM FOR CONFORMAL RTP AND IMRT

适用于适形 RTP 和 IMRT 的自动验证系统

• 批准号: 2870281
• 负责人: MAREK J MARYANSKI
• 金额: $ 9.14万
• 依托单位: MGS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-15 至 2000-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2870281
• 关键词: biomedical automation; computer human interaction; computer program /software; computer system design /evaluation; magnetic resonance imaging; mathematical model; neoplasm /cancer radiation therapy; patient care planning; phantom model; radiation dosage

The use of 3D RTP and IMRT is increasing for patient dose escalation. The major stumbling block to the growth and universal acceptance of these high-tech methods is the lack of available methods to verify that the planned dose will be delivered to the patient correctly. MGS Research Incorporated has developed tissue-equivalent BANG(R) gels that can record permanent images of complete 3D dose distributions of ionizing radiations at therapeutic doses. Dose distributions in BANG gels can be measured with high spatial accuracy and precision using magnetic resonance imaging (MRI). Having verified the potential utility of BANG gel dosimetry for radiation therapy, MGS Research intends to create, in collaboration with SUNY at Stony Brook, a completely automated 3-D conformal RTP and IMRT verification system based on the use of BANG gel phantoms and MRI. Our system will be the only tool available for this purpose and thus we anticipate a sizeable demand. The long-term goal of this project is to deliver a unique product consisting of 1) DICOM-RT compatible software module capable of creating 3D dose data sets from MRI scans of irradiated BANG gel phantoms and of correlating those with the treatment plan data (Phases I and II), 2) a series of specially designed phantoms containing BANG gel inserts and MRI- and CT-sensitive structures (Phase II), and 3) MRI scanning and gel analysis service for customers using BANG gel dosimeters (Phase III). PROPOSED COMMERCIAL APPLICATIONS: There are approximately 2000 Radiation Oncology clinics in the USA. If 1/3 of them purchase the verification phantom at $3500 and the software at $2500 this yields a potential total revenue of $4,000,000. If the system is used for monthly QA of an IMRT dynamic MLC system and if the monthly testing includes the use of 2 Gel inserts at $125 each and an additional $200 for the MR dosimetry, this leads to an annual revenue of $5400 per institution. If 25% of the institutions (the larger university centers) follow this course of action this leads to an additional annual revenue of $2,700,000 per year.

3D RTP和IMRT的使用越来越多，用于患者剂量递增。这些高科技方法的发展和普遍接受的主要障碍是缺乏可用的方法来验证计划的剂量将正确地输送给患者。MGS Research Incorporated开发了组织等效的BANG凝胶，可以记录治疗剂量下电离辐射完整3D剂量分布的永久图像。使用磁共振成像（MRI）可以高空间精度和精确度测量BANG凝胶中的剂量分布。在验证了BANG凝胶剂量测定法用于放射治疗的潜在效用后，MGS Research打算与纽约州立大学斯托尼布鲁克分校合作，基于使用BANG凝胶体模和MRI创建一个完全自动化的3-D适形RTP和IMRT验证系统。我们的系统将是唯一可用于此目的的工具，因此我们预计需求相当大。该项目的长期目标是提供一种独特的产品，该产品由1）DICOM-RT兼容软件模块组成，该模块能够根据辐照BANG凝胶体模的MRI扫描创建3D剂量数据集，并将其与治疗计划数据相关联（I期和II期），2）一系列专门设计的体模，包含BANG凝胶插入物和MRI和CT敏感结构（第二阶段），以及3）为使用BANG凝胶剂量计的客户提供MRI扫描和凝胶分析服务（第三阶段）。拟议的商业应用：美国约有2000家放射肿瘤诊所。 如果其中1/3以3500美元购买验证体模，以2500美元购买软件，则潜在总收入为4，000，000美元。如果该系统用于IMRT动态MLC系统的每月QA，并且如果每月测试包括使用2个凝胶插入物，每个125美元，MR剂量测定额外200美元，则每家机构的年收入为5400美元。如果25%的机构（较大的大学中心）遵循这一行动方针，这将导致每年270万美元的额外年收入。