CLASSIFICATION OF EARLY ONSET DYSTHYMIA

早发性心境恶劣的分类

• 批准号: 2674962
• 负责人: Daniel N Klein
• 金额: $ 20.87万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2674962
• 关键词: anxiety disorders; chronic disease /disorder; clinical depression; disease /disorder classification; disease /disorder proneness /risk; human subject; longitudinal human study; major depression; mental disorder diagnosis; pathologic process; personality disorders; prognosis; social adjustment

Dysthymia is a fairly prevalent condition with substantial social costs. As a nosological construct, it is defined and distinguished from major depression primarily on the basis of longitudinal course. Ironically, however, prospective data on the long-term course of dysthymia are extremely limited. The present proposal seeks funding to continue a ten- year naturalistic follow-up study of early-onset dysthymia, with four waves of assessments at 2 1\2-year intervals. Subjects will include 97 outpatients with DSM-III-R primary, early-onset dysthymia and a comparison group of 45 outpatients with non-chronic major depression. Assessments will include structured diagnostic interviews assessing Axis I and II disorders conducted blind to the baseline evaluation, a comprehensive battery of self-report questionnaires, interviews with knowledgeable informants, and review of medical records. The study will address six major issues: (1) the diagnostic stability of dysthymia; (2) the long-term naturalistic course of dysthymia; (3) clinical, psychosocial, and familial predictors of course and outcome; (4) the heterogeneity of early-onset dysthymia; (5) the stability of comorbid anxiety and personality disorders, and their relationship with dysthymia over time; and (6) the long-term course of social adjustment in dysthymia.

心境恶劣是一种相当普遍的疾病，具有巨大的社会成本。 作为一种疾病分类学结构，它被定义并与重大疾病区分开来。 抑郁症主要基于纵向病程。 讽刺的是， 然而，关于心境恶劣长期病程的前瞻性数据 极其有限。 目前的提案寻求资金，以继续一个十- 早发性恶劣心境障碍四波自然随访研究 每隔2 1\2年进行一次评估。 受试者将包括97名患有DSM-III-R原发性早发性 与45名非慢性抑郁症门诊患者的对照组 萧条 评估将包括结构化诊断访谈 对基线设盲评估轴I和轴II疾病 评价，一套全面的自我报告问卷， 与知识渊博的线人进行访谈，并审查医疗记录。 研究将解决六个主要问题：（1）诊断稳定性 心境恶劣;（2）心境恶劣的长期自然病程;（3） 病程和结局的临床、心理社会和家族预测因素;（4） 早发性恶劣心境的异质性;（5）共病的稳定性 焦虑和人格障碍及其与心境恶劣的关系 随着时间的推移;和（6）长期的社会适应过程中心境恶劣。