PRODUCTION AND ABSORPTION OF INTESTINAL GAS

肠道气体的产生和吸收

• 批准号: 2800217
• 负责人: MICHAEL D LEVITT
• 金额: $ 6.76万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2800217
• 关键词: breath tests; charcoal; clinical research; digestion; enteric bacteria; feces analysis; fructose; gastrointestinal absorption /transport; gastrointestinal disorder; gastrointestinal gas; gastrointestinal sign /symptom; gram positive bacteria; human subject; hydrogen sulfide; irritable bowel syndrome; microorganism metabolism; oligosaccharides; sulfides; thiols

DESCRIPTION: Complaints with regard to intestinal gas are very common. To date, virtually all studies of intestinal gas have been directed to the study of the readily measured, quantitatively important gases (N2, O2, CO2, H2, and CH4). However, these gases have no odor and are unreactive with tissue. Trace quantities of sulfur-containing gases (H2S, methanethiol, and dimethylsulfide) are produced by colonic bacteria. These gases are extremely malodorous, very reactive with tissue, and have a toxicity comparable to that of cyanide. The physiology and clinical importance of these gases in man has received virtually no study. The overall goal of this project is to obtain the first quantitative data on the production and excretion of these sulfur gases in humans, and then determine the pathophysiological importance of these gases. The specific aims of this proposal are to: 1) Measure the rate of excretion of sulfur-containing gases per rectum and the production of these gases by feces, and determine if the excessive production of these gases results from an abnormality of the bacterial flora or excessive availability of appropriate substrates; 2) Determine if the sulfur containing gases are responsible for the malodor of flatus, and if this condition can be treated via the ingestion of or external use of activated charcoal; 3) Determine if sulfur gas production in the colon can be assessed via measurements of sulfur gases excreted in expired air, and determine to what extent production of sulfur gases in the colon is responsible for halitosis; 4) Determine if the production of sulfur gases is an etiologic factor in the irritable colon syndrome, and if this sulfur gas production can be linked to an abnormality of the colonic flora (either increased sulfate-reducing bacteria or decreased bidifidobacteria); and 5) Determine if enhancing the numbers of fecal bifidobacteria (via feeding of fructooligosaccharides) will decrease sulfur gas production and alleviate the symptoms of the irritable colon syndrome.

描述：有关肠道气体的投诉非常常见。至 迄今为止，几乎所有关于肠道气体的研究都指向 研究易于测量的、在数量上重要的气体(氮气、氧气、二氧化碳、 H2和CH4)。然而，这些气体没有气味，不会与 组织。微量含硫气体(硫化氢、甲硫醇和 二甲基硫化物)是由结肠细菌产生的。这些气体是 气味极差，与组织有很强的反应性，并有毒性 与氰化物相当。血管紧张素转换酶的生理学和临床意义 人类体内的这些气体几乎没有得到任何研究。的总目标是 这个项目是为了获得第一批关于生产和生产的定量数据 这些含硫气体在人体内的排泄，然后确定 这些气体的病理生理学重要性。这样做的具体目的是 建议：1)测量含硫的排泄率 每个直肠的气体和粪便产生的这些气体，并确定 如果这些气体的过量生产是由于 细菌菌群或适当底物的过量供应；2) 确定是否由含硫气体引起的异味 如果这种情况可以通过摄入或 外部使用活性碳；3)确定硫磺气体生产是否在 可以通过测量结肠中排出的硫磺气体来评估结肠 呼出的空气，并确定在多大程度上产生硫磺气体 结肠是口臭的罪魁祸首；4)确定硫磺的产生 气体是肠易激综合征的一个病因，如果这一点 硫磺气体的产生可能与结肠菌群的异常有关 (硫酸盐还原细菌增加或双歧杆菌减少)； 以及5)确定是否增加粪便双歧杆菌的数量(通过 饲喂低聚果糖)将减少硫磺气体的产生和 缓解肠易激综合征的症状。