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PRODUCTION AND ABSORPTION OF INTESTINAL GAS

肠道气体的产生和吸收

基本信息

批准号：
6081364
负责人：
MICHAEL D LEVITT
金额：
$ 6.11万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-06-01 至 2001-05-31
项目状态：
已结题

项目摘要

DESCRIPTION: Complaints with regard to intestinal gas are very common. To date, virtually all studies of intestinal gas have been directed to the study of the readily measured, quantitatively important gases (N2, O2, CO2, H2, and CH4). However, these gases have no odor and are unreactive with tissue. Trace quantities of sulfur-containing gases (H2S, methanethiol, and dimethylsulfide) are produced by colonic bacteria. These gases are extremely malodorous, very reactive with tissue, and have a toxicity comparable to that of cyanide. The physiology and clinical importance of these gases in man has received virtually no study. The overall goal of this project is to obtain the first quantitative data on the production and excretion of these sulfur gases in humans, and then determine the pathophysiological importance of these gases. The specific aims of this proposal are to: 1) Measure the rate of excretion of sulfur-containing gases per rectum and the production of these gases by feces, and determine if the excessive production of these gases results from an abnormality of the bacterial flora or excessive availability of appropriate substrates; 2) Determine if the sulfur containing gases are responsible for the malodor of flatus, and if this condition can be treated via the ingestion of or external use of activated charcoal; 3) Determine if sulfur gas production in the colon can be assessed via measurements of sulfur gases excreted in expired air, and determine to what extent production of sulfur gases in the colon is responsible for halitosis; 4) Determine if the production of sulfur gases is an etiologic factor in the irritable colon syndrome, and if this sulfur gas production can be linked to an abnormality of the colonic flora (either increased sulfate-reducing bacteria or decreased bidifidobacteria); and 5) Determine if enhancing the numbers of fecal bifidobacteria (via feeding of fructooligosaccharides) will decrease sulfur gas production and alleviate the symptoms of the irritable colon syndrome.

描述：关于肠气的投诉非常常见。到迄今为止，几乎所有的肠道气体研究都是针对研究容易测量的，定量的重要气体（N2，O2，CO2， H2和CH 4）。然而，这些气体没有气味，并且不与组织. 痕量的含硫气体（H2S、甲硫醇和二甲基硫醚）是由结肠细菌产生的。这些气体极恶臭，与组织反应强烈，具有毒性与氰化物相当。的生理学和临床重要性这些气体在人体内几乎没有得到任何研究。的总目标该项目旨在获得关于生产的第一批定量数据，人体内这些含硫气体的排泄，然后确定这些气体的病理生理重要性。具体目标是建议是：1）测量含硫化合物的排泄率直肠的气体和粪便产生的这些气体，并确定如果这些气体的过量产生是由于细菌植物群或适当底物的过量可用性; 2）确定含硫气体是否是恶臭的原因肠胃气胀，如果这种情况可以通过摄入或外部使用活性炭; 3）确定硫气体的产生是否在结肠可以通过测量排出的含硫气体来评估，呼出的空气，并确定在何种程度上生产的含硫气体中，结肠负责口臭; 4）确定是否生产硫气体是过敏性结肠综合征的病因，如果这含硫气体的产生可能与结肠植物群的异常有关（硫酸盐还原菌增加或双歧杆菌减少）; 和5）确定是否增加粪便双歧杆菌的数量（通过低聚果糖的进料）将减少硫气体的产生，缓解结肠易激综合征的症状。

项目成果

期刊论文数量（36）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Colonic concentrations of hydrogen and methane following colonoscopic preparation with an oral lavage solution.

用口服灌洗液进行结肠镜检查后，结肠中氢气和甲烷的浓度。

DOI：
10.1016/s0016-5107(90)71168-6
发表时间：
1990
期刊：
Gastrointestinal endoscopy
影响因子：
7.7
作者：
Strocchi,A;Bond,JH;Ellis,C;Levitt,MD
通讯作者：
Levitt,MD

Physiological measurements of luminal stirring in the dog and human small bowel.

DOI：
10.1172/jci114873
发表时间：
1990-11
期刊：
The Journal of clinical investigation
影响因子：
0
作者：
Michael D. Levitt;J. K. Fume;Alessandra Strocchi;B. W. Anderson;David Levitt
通讯作者：
Michael D. Levitt;J. K. Fume;Alessandra Strocchi;B. W. Anderson;David Levitt

Use of maltose hydrolysis measurements to characterize the interaction between the aqueous diffusion barrier and the epithelium in the rat jejunum.

使用麦芽糖水解测量来表征大鼠空肠中水扩散屏障和上皮之间的相互作用。