FUNCTIONAL ORGANIZATION OF THE FRONTAL EYE FIELD

前眼区的功能组织

• 批准号: 2608572
• 负责人: Charles Joseph Bruce
• 金额: $ 20.6万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-03-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2608572
• 关键词: Macaca mulatta; brain mapping; eye movements; neural information processing; neurophysiology; saccades; smooth pursuit eye movement; visual cortex; visual fields; visual pathways; visual stimulus; visual tracking

The proposed experiments investigate the functional organization of the primate frontal eye field (FEF) and its role in the execution of voluntary eye movements, principally saccade and smooth pursuit. For both types of movement, the essential steps are to 1. Select one target from multiple possibilities, 2. Process the spatial parameters of that target, and 3. Reckon the movement metrics that will best track the target. Cortical mechanisms underlying each of these processes will be analyzed: Aim 1 is to analyze FEF involvement in target selection by teaching monkeys to select peripheral targets based on color and studying the activity of target selection, and eye movement execution. Pursuit- related neurons will be studied during selection between peripheral targets moving in different directions; I hypothesize that these neurons will response on the basis of the selected target, being excited when the target moving in their preferred direction is selected. Target location will be critical factor in analogous experiments of saccade-related neurons, which will also be tested for correlates of the rapid target selection engendered by the express saccade paradigm. Aim 2 is to analyze the types of spatial target parameters derived from sensory inputs by FEF neurons. Saccade to moving targets are accurate despite displacement of the target during the time needed to register its position and beyond FEF will be ascertained by quantitative mapping response fields of saccade-related FEF cells in conjunction with saccade to moving targets. Similarly, smooth pursuits is guided by not only target velocity, but also by smooth and transient image accelerations and by positional target error. The contributions of each of these distinct parameters, as well as orbital eye position and velocity, to the activity of FEF pursuit neurons will be quantified with a methodology used to analyze pursuit-related activity in the cerebellar flocculus. Aim 3 is to analyze FEF's role in adaptive influences on eye movement metric by conditioning the oculomotor responses to specific target steps and ramps. Saccade direction will be conditioned by instantaneous displacements of target location while the eye is in flight, and pursuit direction by abrupt changes in target motion direction imposed immediately after pursuit initiation. Correlated changes in motor specification underlying this learning. Aim 4 is to map the entire FEF representations for saccadic and smooth pursuit eye movements while carrying out the previous 3 aims, and to also explore the arcuate region of frontal lobe cortex for possible representations of vergence eye movements and eyelid blinks. Overall, the proposed experiments will help define the role of the cerebral cortex in effecting different types of eye movements, and thereby contribute to diagnosis and treatment of oculomotor disturbances in neurological disease, and even psychiatric disorders such as schizophrenia.

所提出的实验调查的功能组织 灵长类额叶眼场（FEF）及其在执行 随意的眼球运动，主要是扫视和平滑追踪。 为 这两种类型的运动，基本步骤是1。选择一个目标 从多种可能性，2。处理空间参数， 目标，3。计算最能跟踪 目标 这些过程中的每一个背后的皮层机制将是 分析：目的1是分析FEF参与靶点选择， 教猴子根据颜色选择周边目标， 目标选择和眼动执行活动。 追击- 相关神经元将在周围神经元之间的选择过程中进行研究。 目标向不同方向移动;我假设这些神经元 将响应的基础上选定的目标，被激发时， 选择在其优选方向上移动的目标。 目标位置 将是与扫视相关的类似实验中的关键因素 神经元，这也将被测试的相关性的快速目标 选择产生的快速扫视范例。 目标二是 分析了空间目标参数的类型， FEF神经元的输入。 对移动目标的扫视是准确的， 在登记其所需时间内， 通过定量绘图确定FEF的位置和范围 与扫视相关的FEF细胞的反应场 移动目标。 同样，顺利的追求不仅受到 目标速度，但也通过平滑和瞬态图像加速度， 定位目标误差。 每一个独特的贡献 参数，以及眶眼位置和速度， 的FEF追求神经元将被量化的方法，用于 分析小脑小叶中的追踪相关活动。 目标3是 分析FEF在眼动度量的适应性影响中的作用， 调节眼球对特定目标步幅和斜坡的反应。 扫视方向将由 目标位置，而眼睛是在飞行中，和追求方向， 目标运动方向的突然变化 开始追击 电机规格的相关变更 这个学习。 目标4是映射整个FEF表示， 扫视和平滑的追踪眼球运动，同时进行先前的 3目的，并探讨额叶皮质弓状区， 聚散眼球运动和眼睑眨眼的可能表示。 总的来说，拟议的实验将有助于确定 大脑皮层影响不同类型的眼球运动， 从而有助于眼科疾病的诊断和治疗 神经系统疾病，甚至精神疾病， 精神分裂症