NEURAL MECHANISMS UNDERLYING COMPLEX, PURPOSEFUL MOTOR ACTIONS

复杂、有目的的运动行为背后的神经机制

• 批准号: 6282823
• 负责人: APOSTOLOS GEORGOPOULOS
• 金额: $ 4.39万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-15 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282823
• 关键词: biomedical resource; cognition; female; human subject; magnetic resonance imaging; male; nervous system

This collaborative effort is an extension of work supported by a grant funded for monkey studies (RO1 NS17413-20, 7/1/96 - 6/30/2001). It is conducted in a synergistic fashion together with similar and parallel experiments to be carried out with humans using. The general goal of this research is to understand the neural mechanisms underlying praxis, that is complex, purposeful motor actions; these mechanisms are largely unknown. In the monkey studies, rhesus monkeys are trained to perform tasks commonly used to determine the presence of constructional apraxia in brain-damaged human patients, including copying simple geometrical figures, assembling objects out of component parts, and route finding in a maze. The activity of single cells during task performance is recorded in key cortical areas of the monkey brain using a 7-microelectrode system. We have started examining in human subjects using fMRI at 4 Tesla which regions are activated during identical or analogous tasks. Extensive preliminary data has been collected demonstrating that activity is primarily in the frontal cortex, a finding that was unexpected.

这项协作努力是由 资助猴子研究的赠款（RO 1 NS 17413 -20，1996年1月7日至2001年6月30日）。 它是以协同方式与类似的， 与人类进行的平行实验。 总 这项研究的目的是了解神经机制， 潜在的实践，即复杂的，有目的的运动动作;这些 机制在很大程度上是未知的。 在对猴子的研究中， 被训练来执行通常用于确定 脑损伤患者的结构性失用症，包括 复制简单的几何图形，组装物体， 零部件和在迷宫中寻找路线。 活动单 细胞在任务执行过程中被记录在关键的皮质区的 使用7微电极系统的猴脑。 我们已经开始 用4特斯拉的功能磁共振成像检查人类受试者的哪些区域 在相同或类似的任务中激活。 广泛的初步 收集的数据表明，活动主要是在 额叶皮层，这是一个出乎意料的发现。