NEURAL MECHANISMS UNDERLYING COMPLEX, PURPOSEFUL MOTOR ACTIONS

复杂、有目的的运动行为背后的神经机制

• 批准号: 6314421
• 负责人: APOSTOLOS GEORGOPOULOS
• 金额: $ 3.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314421
• 关键词: bioimaging /biomedical imaging; biomedical resource; cognition; female; human subject; magnetic resonance imaging; male; nervous system

This collaborative effort is an extension of work supported by a grant funded for monkey studies (RO1 NS17413-20, 7/1/96 - 6/30/2001). It is conducted in a synergistic fashion together with similar and parallel experiments to be carried out with humans using. The general goal of this research is to understand the neural mechanisms underlying praxis, that is complex, purposeful motor actions; these mechanisms are largely unknown. In the monkey studies, rhesus monkeys are trained to perform tasks commonly used to determine the presence of constructional apraxia in brain-damaged human patients, including copying simple geometrical figures, assembling objects out of component parts, and route finding in a maze. The activity of single cells during task performance is recorded in key cortical areas of the monkey brain using a 7-microelectrode system. We have started examining in human subjects using fMRI at 4 Tesla which regions are activated during identical or analogous tasks. Extensive preliminary data has been collected demonstrating that activity is primarily in the frontal cortex, a finding that was unexpected.

这种协作工作是由