DEEP STRUCT NEUROPHYSIOLOGY USING MULTICHANNEL SILICON ELECTRODES: HIPPOCAMPUS

将微探针植入大脑深部结构， 海马，斯卡帕神经节，下丘，耳蜗核 深层皮质层仍然是一个越来越受关注的领域 我们的外部合作者。 Buzsaki博士的演讲 国家会议以及他的出版物激起了巨大的 海马体中的记录引起了很多人的兴趣。 挑战 将探针用于这些制备包括保持探针， 在插入过程中保持直线轨迹，精确定位 放置在大脑表面以下的小区域， 插入后稳定。 我们正在与上市集团合作 合作研究人员来解决这些问题。 探针与 长柄在插入过程中趋于弯曲。 几名调查人员在 使用套管准备将探针插入深部结构。 其他人正在探索涂层，以增强刚性或附着力 小的，更刚性的结构到衬底的背面。 新 插入方法也正在评估其能力， 增强插入的直线性。 自定义探头已被 由上述调查人员设计，并已制作， 由安装并粘结到所需连接器的中心提供。 的 在这个科学子项目中所做的工作使许多人受益， 研究人员使用新的放置技术，不仅在大脑深处， 结构，但在其他领域也是如此。

The placement of microprobes into deep brain structures such as hippocampus, Scarpa's ganglion, inferior colliculus, cochlear nucleus and deep cortical layers continues to be a growing area of interest for our external collaborators. Dr. Buzsaki's presentations at national meetings as well as his publications have stirred a great deal of interest from those recording in hippocampus. Challenges in using the probes for these preparations include holding the probe and maintaining a straight trajectory during insertion, accurate site placement in small regions well below the brain surface, and stabilization after insertion. We are working with the listed group of collaborative researchers to solve these problems. Probes with long shanks tend to bend during insertion. Several investigators are using cannular preparations to insert probes into deep structures. Others are exploring the coatings to enhance rigidity, or attachment of small, more rigid structures to the back of the substrate. New methods for insertion are also being evaluated for their ability to enhance the straightness of insertions. Custom probes have been designed by the above investigators and have been fabricated and provided by the Center mounted and bonded to desired connectors. The work done within this scientific sub-project benefits many investigators with new placement techniques, not only in deep brain structures but in other areas as well.