BALTIMORE LONGITUDINAL STUDY OF AGING--PHYSIOLOGY, BIOCHEMISTRY & PSYCHOLOGY

巴尔的摩老龄化纵向研究(BLSA)是一项持续的、多方面的 一项旨在了解老年人衰老过程的学科研究项目 男人和女人。纵向变化的评估是通过拥有一组 不同性别、不同年龄的成年人的社区居住对象 寿命，每两年回来进行一次全面评估。主修 这项研究的目标是更好地了解各种年龄相关的变化 器官系统及其相互关系，以表征这一转变 从正常到病理性衰老及其相关的功能变化 这些系统会导致特定疾病的发展和死亡率。 BLSA的目的有四个：1)获得重复测量 生理、病理、生化和心理变量 纵向研究参与者；2)比较功能水平 在年龄和性别队列中反复测量；3)跟踪 个人参与者和年龄以上的参与者团体- 相关的终点和疾病事件；以及4)识别特征 可能是生物衰老的标志的个体参与者，以及 分析它们对临床结果的影响。横截面 还得到了多个参数的表征和差异 与年龄、性别和种族有关的数据被量化。老龄化、世俗和时期 对影响进行了检验。营养等变量之间的关系 习惯，习惯的体力活动水平，以及对年龄的适应- 身体残疾与糖代谢、心血管疾病相关 正在检查其功能和具体的疾病结局。对一些问题的研究 BLSA参与者在约翰霍普金斯大学贝维尤医疗中心的 GCRC，包括营养模式和身体状况的评估 功能和口服葡萄糖耐量试验。在过去的一年里 已经发表了与糖尿病和血糖有关的报告。 新陈代谢，骨关节炎，阿尔茨海默病，心血管疾病， 前列腺癌与女性健康。BLSA是壁内的一部分 国家老龄研究所研究计划和全额资助 被美国国家安全局。GCRC工作人员采访了BLSA的一个子集，以 营养评估。在约500名受试者中，有18人在 在报告所述期间，这些人被送往GCRC进行检测。招生人数 这项研究的期限正在进行中。

The Baltimore Longitudinal Study of Aging (BLSA) is an ongoing, multi- disciplinary research project aimed at understanding the aging process in men and women. Longitudinal changes are assessed by having a cohort of community-dwelling subjects of both sexes, and ages across the adult lifespan, who return every two years for a comprehensive evaluation. Major goals of the study are to better understand age-related changes in various organ systems and their interrelationships, to characterize the transition from normal to pathological aging and to relate functional changes in these systems to the development of specific diseases and mortality. The purposes of the BLSA are fourfold: 1) to obtain repeated measures of physiological, pathological, biochemical, and psychological variables on longitudinal study participants; 2) to compare levels of function repeatedly measured in age and sex cohorts; 3) to follow changes in individual participants and groups of participants up to and beyond age- related endpoints and disease events; and 4) to identify characteristics of individual participants that may be markers of biological aging, and to analyze their influence on clinical outcomes. Cross-sectional characterization of multiple parameters is also obtained and differences related to age, sex and race are quantified. Aging, secular, and period effects are examined. Relationships between such variables as nutritional habits, customary levels of physical activity, and adaptations to age- associated physical disability with glucose metabolism, cardiovascular function and specific disease outcome are being examined. Studies of some BLSA participants are conducted on Johns Hopkins Bayview Medical Center's GCRC and include assessments of nutritional patterns and physical function, and oral glucose tolerance testing. Over the past year major reports have been published in relationship to diabetes and glucose metabolism, osteoarthritis, Alzheimer's Disease, cardiovascular disease, prostate cancer and women's health. The BLSA is part of the Intramural Research Program of the National Institutes of Aging and wholely supported by the NIA. The GCRC staff interviewed a subset of the BLSA for nutritional assessment. Eighteen of approximately 500 subjects seen during the reporting period were admitted to the GCRC for testing. The enrollment period for this study is ongoing.