BALTIMORE LONGITUDINAL STUDY OF AGING--PHYSIOLOGY, BIOCHEMISTRY & PSYCHOLOGY

巴尔的摩老龄化纵向研究（BLSA）是一个正在进行的多学科研究项目，旨在了解男性和女性的衰老过程。纵向变化的评估有一个队列的社区居住的主题的两种性别，和年龄在整个成年人的生命周期，谁返回每两年一次全面的评估。该研究的主要目标是更好地了解各种器官系统中与年龄相关的变化及其相互关系，描述从正常到病理性衰老的过渡，并将这些系统中的功能变化与特定疾病和死亡率的发展联系起来。BLSA的目的有四个：1）获得对纵向研究参与者的生理、病理、生化和心理变量的重复测量; 2）比较年龄和性别队列中重复测量的功能水平; 3）跟踪个体参与者和参与者组的变化，直至和超过年龄相关终点和疾病事件;以及4）识别个体参与者的特征，这些特征可能是生物老化的标志，并且分析它们对临床结果的影响。还获得了多个参数的横截面表征，并量化了与年龄、性别和种族相关的差异。老化，长期和期间的影响进行了检查。营养习惯、习惯性体力活动水平、对与年龄相关的身体残疾的适应与葡萄糖代谢、心血管功能和特定疾病结果之间的关系正在研究中。对一些BLSA参与者的研究在约翰霍普金斯湾景医疗中心的GCRC上进行，包括营养模式评估和口服葡萄糖耐量试验。在过去的一年里，发表了关于糖尿病和葡萄糖代谢、骨关节炎、阿尔茨海默病、心血管疾病、前列腺癌和妇女健康的主要报告。BLSA是国家老龄化研究所校内研究计划的一部分，并得到NIA的全力支持。GCRC工作人员对379名BLSA参与者进行了营养评估。在本报告期内观察到的约500例受试者中，有25例进入GCRC进行检测。本研究的入组期正在进行中。

The Baltimore Longitudinal Study of Aging (BLSA) is an ongoing, multidisciplinary research project aimed at understanding the aging process in men and women. Longitudinal changes are assessed by having a cohort of community-dwelling subjects of both sexes, and ages across the adult lifespan, who return every two years for a comprehensive evaluation. Major goals of the study are to better understand age-related changes in various organ systems and their interrelationships, to characterize the transition from normal to pathological aging, and to relate functional changes in these systems to the development of specific diseases and mortality. The purposes of the BLSA are fourfold: 1) to obtain repeated measures of physiological, pathological, biochemical, and psychological variables on longitudinal study participants; 2) to compare levels of function repeatedly measured in age and sex cohorts; 3) to follow changes in individual participants and groups of participants up to and beyond age-related endpoints and disease events; and 4) to identify characteristics of individual participants that may be markers of biological aging, and to analyze their influence on clinical outcomes. Cross-sectional characterization of multiple parameters is also obtained and differences related to age, sex and race are quantified. Aging, secular, and period effects are examined. Relationships between such variables as nutritional habits, customary levels of physical activity, and adaptations to age-associated physical disability with glucose metabolism, cardiovascular function and specific disease outcome are being examined. Studies of some BLSA participants are conducted on Johns Hopkins Bayview Medical Center's GCRC and include assessments of nutritional patterns and oral glucose tolerance testing. Over the past year, major reports have been published in relation to diabetes and glucose metabolism, osteoarthritis, Alzheimer's Disease, cardiovascular disease, prostate cancer, and women's health. The BLSA is part of the Intramural Research Program of the National Institute of Aging and wholy supported by the NIA. The GCRC staff intereviewed 379 of the BLSA participants for nutritional assessment. Twenth-five of approximately 500 subjects seen during the reporting period were admitted to the GCRC for testing. The enrollment period for this study is ongoing.