AGE CHANGES IN PULMONARY FUNCTION

肺功能的年龄变化

• 批准号: 2565739
• 负责人: J L FOZARD
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2565739
• 关键词: age difference; aging; clinical research; disease /disorder proneness /risk; gender difference; health surveys; human subject; leukocyte count; longitudinal human study; lung; prognosis; respiratory airway volume; respiratory disorder epidemiology; respiratory function

The BLSA Program in Pulmonary Aging has focused on: a. Longitudinal changes in FEV1 in healthy, non-smoking men and women. Longitudinal analyses of changes in FEV1 were conducted among 91 men and 82 women who had no history of respiratory problems and had never smoked cigarettes. The FEV1 data were modeled using a mixed-effects regression model and longitudinal percentile distributions of FEV1 level were constructed. The findings showed 1) the average longitudinal rate of decline in FEV1 was approximately 240-340 ml/decade in men and women, 2) none of the participants exhibited a sustained improvement in FEV1, and 3) between-subjects variability is greater in men than women and increases with age in men, but decreases with age in women. The age- and gender-specific percentile distributions are the first nomograms which reflect age differences in the variability in pulmonary function. b. Relationship of peripheral leukocyte count to longitudinal changes in FEV1 in healthy BLSA subjects. The effect of leukocyte count on ventilatory lung function is being studied using longitudinal changes in FEV1 of healthy nonsmoking BLSA subjects as outcome. c. Age associated changes in Maximal Inspiratory Pressure (MIP). Cross sectional analyses of data consisting of 400 men and 295 women ranging in age between 20 and 90 years were done. The average MIP of females across the different age groups was about two thirds that of men. Reference equations for MIP in a healthy subset are being constructed.

BLSA在肺老化方面的计划侧重于： A.健康、不吸烟的男性和女性FEV1的纵向变化。 对91名男性进行了FEV1变化的纵向分析 82名女性，她们没有呼吸道疾病病史，也从未 抽过烟。使用混合效应对FEV1数据进行建模 FEV1水平的回归模型及纵向百分位数分布 都是被建造的。研究结果表明：1)平均纵向率 男性FEV1下降的幅度约为240-340毫升/十年， 女性，2)没有一个参与者表现出持续的进步 FEV1和3)受试者之间的变异性男性大于女性 男性随年龄增长，女性随年龄增长而减少。这个 年龄和性别特定的百分位数分布是第一张诺模图 这反映了肺功能变异性的年龄差异。 B.外周血白细胞计数与精神分裂症纵向变化的关系 健康BLSA受试者的FEV1。外周血白细胞计数对血液流变学的影响 呼吸性肺功能正在使用纵向变化进行研究 以健康非吸烟BLSA受试者的FEV1为结果。 C.最大吸气压(MIP)与年龄相关的变化。十字 400名男性和295名女性数据的横断面分析 年龄在20岁到90岁之间。女性的平均MIP 在不同年龄段，这一比例约为男性的三分之二。 健康子集中MIP的参考方程正在构建中。