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USE OF INTRAVENOUS CHOLINE IN TOTAL PARENTERAL NUTRITION (TPN)

USE OF INTRAVENOUS CHOLINE IN TOTAL PARENTERAL NUTRITION (TPN)
在全肠外营养 (TPN) 中使用静脉注射胆碱
批准号：
6281703
负责人：
ALAN L. BUCHMAN
金额：
$1.36万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6281703
关键词：
choline choline deficiency clinical research diet therapy dietary supplements human subject human therapy evaluation lipid disorder liver disorder nutrition related tag parenteral feedings

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中文摘要
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英文摘要
Choline is necessary for the normal functioning of the mammalian organism. Hepatic steatosis associated with the use of total parenteral nutrition (TPN) is caused by choline deficiency. The aim of this study is to confirm that choline-supplemented TPN causes a decrease or resolution of hepatic steatosis in long term TPN patients with choline deficiency manifested by hepatic steatosis, and to determine whether recurrence can be prevented by continued choline supplementation. Subjects will be randomized to receive choline in their TPN or placebo.
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