TREATMENT OF HEPATIC STEATOSIS ASSOCIATED WITH TOTAL PARENTAL NUTRITION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胆碱缺乏会导致超过50%需要长期肠外营养的患者出现肝脏脂肪变性(脂肪肝)。本研究的目的是确定在静脉(经静脉)营养液(TPN)中加入氯化胆碱是否可以治疗与长期使用TPN相关的体内低水平胆碱(胆碱缺乏)或肝脏脂肪变性(脂肪肝)。氯化胆碱是一种研究或研究药物，FDA仅批准用于此类研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Choline deficiency causes hepatic steatosis (fatty liver) in over 50% of patients who require long-term parenteral nutrition. The purpose of this study is to determine if the addition of choline chloride to intravenous (received via a vein) nutrition solutions (TPN) can treat low levels of choline in the body (choline deficiency) or hepatic steatosis (fatty liver) associated with long-term use of TPN. Choline chloride is a research or investigational drug and is approved by the FDA only for use in studies such as this one.