USE OF INTRAVENOUS CHOLINE IN TOTAL PARENTERAL NUTRITION (TPN)

在全肠外营养 (TPN) 中使用静脉注射胆碱

• 批准号: 6121133
• 负责人: ALAN L. BUCHMAN
• 金额: $ 1.51万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121133
• 关键词: choline; choline deficiency; clinical research; diet therapy; dietary supplements; human subject; human therapy evaluation; lipid disorder; liver disorder; nutrition related tag; parenteral feedings

Choline is necessary for the normal functioning of the mammalian organism. Hepatic steatosis associated with the use of total parenteral nutrition (TPN) is caused by choline deficiency. The aim of this study is to confirm that choline-supplemented TPN causes a decrease or resolution of hepatic steatosis in long term TPN patients with choline deficiency manifested by hepatic steatosis, and to determine whether recurrence can be prevented by continued choline supplemen-tation. Subjects will be randomized to receive choline in their TPN or placebo (no choline).

胆碱是哺乳动物机体正常功能所必需的。与使用全胃肠外营养（TPN）相关的肝脏脂肪变性是由胆碱缺乏引起的。 本研究的目的是证实补充胆碱的TPN可减少或缓解表现为肝脂肪变性的胆碱缺乏的长期TPN患者的肝脂肪变性，并确定持续补充胆碱是否可预防复发。 受试者将随机接受TPN中的胆碱或安慰剂（无胆碱）。