A NEW COMBINATORIAL SYNTHESIZER

本研究的总体目标是开发一种新的实验室仪器，能够合成和分析组合阵列的“磁带盒”格式。所提出的格式允许大阵列，以方便地合成和分析在一个紧凑的体积，磁带格式提供了显着的处理优势，目前正在调查的二维“芯片”格式的各种研究人员。第一阶段的研究将涉及开发一个适当的化学磁带/矩阵/阵列系统，合成一个模型组合阵列上的磁带，并验证合成方法的化学分析阵列成员，并通过抗体识别的阵列成员。第一阶段研究的成功完成将证明组合阵列可以以磁带格式合成。第二阶段的研究将侧重于开发一种原型仪器，自动合成用户设计的阵列。拟议的商业应用：成功完成拟议的研究将导致一个新的仪器合成和分析组合阵列。

The overall objective of this research is to develop a new laboratory instrument capable of both synthesizing and analyzing combinatorial arrays in a "tape cassette" format. The proposed format allows large arrays to be conveniently synthesized and analyzed within a compact volume, The tape format offers significant handling advantages over the two dimensional "chip" format currently under investigation by a variety of researchers. Phase I research will involve developing an appropriate chemistry for the tape/matrix/array system, synthesizing a model combinatorial array on a tape, and validating the synthesis method by chemical analysis of array members, and by antibody recognition of an array member. Successful completion of Phase I research would demonstrate that combinatorial arrays can be synthesized in a tape format. Phase II research would then focus on developing a prototype instrument that automatically synthesizes arrays designed by the user. PROPOSED COMMERCIAL APPLICATIONS: Successful completion of the proposed research would lead to a new instrument for synthesizing and analyzing combinatorial arrays.