Sensitive Detection of Urinary Biomarkers of Renal Injury

描述（由申请人提供）：如果成功，该项目将产生一种检测芯片，该芯片可以收集、稳定并准确量化一系列指示肾损伤的生物标志物。它的灵敏度和准确性使它能够检测缓慢发生的肾损害。它的多分析能力可以区分不同的肾损害机制。它应该适用于自动检测，因此在临床环境中可用。

DESCRIPTION (provided by applicant): If successful, this program will result in an assay chip that collects, stabilizes, and accurately quantifies a suite of biomarkers indicative of renal injury. Its sensitivity and accuracy may enable it to detect slowly occurring renal damage. Its multianalyte capability could distinguish different mechanisms of renal damage. It should be adaptable to automated assays and hence usable in a clinical setting. PUBLIC HEALTH RELEVANCE: The need for an early diagnosis of renal injury is important for patients with renal disease, for those undergoing kidney transplantation, and for patients undergoing drug therapy, especially new drugs that may cause renal damage. Traditional biomarkers are not capable of detecting early stages of renal damage. For this reason there is high interest and activity in the search for new biomarkers of renal damage. There is less activity in developing new assay formats that use new biomarkers. We propose to develop a such an assay. We propose developing a diagnostic chip capable of collection, stabilization, and highly sensitive and accurate quantification of a suite of biomarkers indicative of renal damage.